Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity
Formulating a Stable Mannitol Infusion while Maintaining Hyperosmolarity
复制标题
配制稳定的甘露醇输液，同时保持高渗透压
作者：
Oisín N. Kavanagh;F. Hogan;Caoimhe Murphy;D. Croker;G. Walker
甘露醇输注通常用于治疗创伤性脑损伤后的颅内高压。长期以来，已知甘露醇存在稳定性问题，具体而言，甘露醇在环境条件下从大于10%w/v的溶液中重结晶。这可能发生在任何时候，无论是在药房货架上还是在医疗过程中。本研究描述了20% w/v甘露醇输注液（临床上最常用的浓度）的稳定性限度，并提出了许多更安全、稳定且可调的甘露醇与临床可接受的渗透剂（氯化钠、山梨醇和甘油）组合的高渗制剂。
Mannitol infusion is commonly used in the treatment of intracranial hypertension following traumatic brain injury. It has long been known to have stability issues, specifically, mannitol recrystallises from solutions greater than 10% w/v in ambient conditions. This can happen at any time, whether on the pharmacy shelf or during a medical procedure. This study describes the stability limits of 20% w/v mannitol infusion (the most common strength used clinically) and proposes a number of safer, stable and tuneable hyperosmotic formulations of mannitol in combination with clinically acceptable osmotic agents (NaCl, sorbitol and glycerol).
影响因子：
4.8
作者：
Mangat, Halinder S.;Wu, Xian;Hartl, Roger
通讯作者：
Hartl, Roger