An SNP within the Angiotensin-Converting Enzyme Distinguishes between Sprint and Distance Performing Alaskan Sled Dogs in a Candidate Gene Analysis
An SNP within the Angiotensin-Converting Enzyme Distinguishes between Sprint and Distance Performing Alaskan Sled Dogs in a Candidate Gene Analysis
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DOI：
10.1093/jhered/esr022
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发表时间：
2011-09-01
影响因子：
3.1
通讯作者：
Ostrander, Elaine A.
中科院分区：
文献类型：
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作者：
Huson, Heather J.;Byers, Alexandra M.;Ostrander, Elaine A.
阿拉斯加雪橇犬提供了一个独特的机制，研究遗传学的精英运动表现。他们是一组混合品种的狗，由多个常见的品种，和一个独特的品种实体只看到作为雪橇狗组合的一部分。阿拉斯加雪橇犬根据它们的比赛技巧分为两大类。距离犬能够在10天内跑超过1000英里，而短跑犬跑的距离要短得多，大约30英里，但速度更快，即18-25英里/小时。找到区分这两种类型的表现者的基因可能会阐明人类运动表现的基因贡献者。在这项研究中，我们测试了2个候选基因的多态性之间的关联;血管紧张素转换酶（ACE）和肌肉生长抑制素（MSTs）和174阿拉斯加雪橇犬的速度和耐力性能增强。我们在ACE基因中观察到81个新的遗传变异，在MPEG4基因中观察到4个新的遗传变异，包括ACE基因中的一个多态性，该多态性显著（P值2.38 x 10（-5））区分了短跑和长跑人群。
The Alaskan sled dog offers a unique mechanism for studying the genetics of elite athletic performance. They are a group of mixed breed dogs, comprised of multiple common breeds, and a unique breed entity seen only as a part of the sled dog mix. Alaskan sled dogs are divided into 2 primary groups as determined by their racing skills. Distance dogs are capable of running over 1000 miles in 10 days, whereas sprint dogs run much shorter distances, approximately 30 miles, but in faster times, that is, 18-25 mph. Finding the genes that distinguish these 2 types of performers is likely to illuminate genetic contributors to human athletic performance. In this study, we tested for association between polymorphisms in 2 candidate genes; angiotensin-converting enzyme (ACE) and myostatin (MSTN) and enhanced speed and endurance performance in 174 Alaskan sled dogs. We observed 81 novel genetic variants within the ACE gene and 4 within the MSTN gene, including a polymorphism within the ACE gene that significantly (P value 2.38 x 10(-5)) distinguished the sprint versus distance populations.