Circulating Epstein-Barr virus in children living in malaria-endemic areas
Circulating Epstein-Barr virus in children living in malaria-endemic areas
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DOI：
10.1111/j.1365-3083.2005.01589.x
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发表时间：
2005-05-01
影响因子：
3.7
通讯作者：
Bejarano, MT
中科院分区：
文献类型：
--
作者：
Rasti, N;Falk, KI;Bejarano, MT
生活在疟疾流行地区的儿童伯基特淋巴瘤（BL）发病率很高，其病因涉及恶性疟原虫疟疾和EB病毒（EBV）感染。急性疟疾感染损害EBV特异性免疫应答，从而增加循环中携带EBV的B细胞的数量。为了进一步了解疟疾感染对疟疾流行区儿童EBV持续性的潜在影响，我们研究了73名患有和不患有急性疟疾感染的加纳儿童血浆中无细胞EBV-DNA的发生和定量。在40%的样本中检测到病毒DNA（47%的疟疾感染者和34%的非疟疾组），但在加纳成年人和健康的意大利儿童的血浆中没有检测到病毒DNA。这些发现提供的证据表明，病毒再激活是常见的儿童生活在疟疾流行地区，并可能有助于地方性BL的风险增加。数据还表明，EBV感染和持续性的流行病学在世界不同地区有所不同。
Children living in malaria-endemic regions have high incidence of Burkitt's lymphoma (BL), the aetiology of which involves Plasmodium falciparum malaria and Epstein-Barr virus (EBV) infections. Acute malarial infection impairs the EBV-specific immune responses with the consequent increase in the number of EBV-carrying B cells in the circulation. To further understand the potential influence of malarial infection on the EBV persistence in children living in malaria-endemic areas, we studied the occurrence and quantified cell-free EBV-DNA in plasma from 73 Ghanaian children with and without acute malarial infection. Viral DNA was detected in 40% of the samples (47% in the malaria-infected and 34% in the nonmalaria group) but was absent in plasma from Ghanaian adults and healthy Italian children. These findings provide evidence that viral reactivation is common among children living in malaria-endemic areas, and may contribute to the increased risk for endemic BL. The data also suggest that the epidemiology of EBV infection and persistence varies in different areas of the world.