Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney
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DOI：
10.14670/hh-21.7
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发表时间：
2006-01-01
影响因子：
2
通讯作者：
Enzan, H
中科院分区：
文献类型：
--
作者：
Kuroda, N;Hes, O;Enzan, H
黏液性管状梭形细胞癌是近年来发现的一种新的肿瘤。本文应用免疫组织化学方法检测了16例MTSCC中神经内分泌标志物神经元特异性烯醇化酶（NSE）、嗜铬素A（chromogranin A）和突触素（synaptophysin）的表达。患者的性别比（男：女）为4：12。正常肾组织中，远端小管和集合管NSE阳性，而嗜铬粒蛋白A和突触素未见阳性结构。所有MTSCC均呈NSE阳性反应。此外，16例MTSCC肿瘤中有15例（93.8%）显示嗜铬粒蛋白A或突触素或两者均表达。MTSCC可能是肾肿瘤中最常发生神经内分泌分化的肿瘤之一。
Mucinous tubular and spindle cell carcinoma (MTSCC) is a new tumorous entity which has been recently established. In this article, we examined the expression of neuroendocrine markers including neuron specific enolase (NSE), chromogranin A and synaptophysin in 16 cases of MTSCC using immunohistochemistry. The sex ratio (male: female) of the patients was 4:12. In normal kidney, distal tubules or collecting ducts were positive for NSE, but no structures were positive for chromogranin A or synaptophysin. All MTSCCs showed a positive reaction for NSE. Additionally, fifteen of sixteen neoplasms (93.8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Finally, it is possible that MTSCC may be one of renal neoplasms which frequently exhibit the neuroendocrine differentiation.