Rickettsiae as Emerging Infectious Agents
Rickettsiae as Emerging Infectious Agents
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DOI：
10.1016/j.cll.2017.01.009
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发表时间：
2017-06-01
影响因子：
1.7
通讯作者：
Walker, David H.
中科院分区：
文献类型：
--
作者：
Fang, Rong;Blanton, Lucas S.;Walker, David H.
随着分子遗传学的进步，越来越多的病原性立克次体被鉴定出来。致病立克次体通过节肢动物等媒介传播到患者皮肤，然后传播到微血管内皮细胞。临床表现为发热伴头痛和肌痛，3-5天后出现皮疹。临床症状的未分化性质、流行病学知识以及患者的旅行和接触节肢动物病媒的病史对于经验性应用抗菌药物治疗至关重要。多西环素是目前治疗斑点热群和斑疹伤寒群立克次体最有效的抗生素。
With advances in molecular genetics, more pathogenic rickettsia] species have been identified. Pathogenic rickettsiae are transmitted by vectors, such as arthropods, into the patient's skin and then spread into the micro vascular endothelial cells. Clinical manifestations are characterized by fever with headache and myalgias, followed by rash 3 to 5 days later. The undifferentiated nature of clinical symptoms, knowledge of the epidemiology, and the patient's history of travel and exposure to arthropod vectors are critical to the empiric administration of antimicrobial therapy. Doxycycline is currently the most effective antibiotic for treatment of all spotted fever group and typhus group rickettsioses.