Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O-specific polysaccharide conjugates in children
Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O-specific polysaccharide conjugates in children
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DOI：
10.1086/314759
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发表时间：
1999-06-01
影响因子：
6.4
通讯作者：
Schneerson, R
中科院分区：
文献类型：
--
作者：
Ashkenazi, S;Passwell, JH;Schneerson, R
志贺氏菌的o特异性多糖偶联物在年轻人中是安全且具有免疫原性的，而索内志贺氏菌偶联物具有保护作用[1-3]。志贺氏菌病主要是儿童疾病；因此，我们在4- 7岁儿童中研究了索内沙门氏菌和福氏志贺氏菌2a结合物的安全性和免疫原性。局部和全身反应最小。第一次注射这两种结合物引起血清IgG仅对同源脂多糖（LPS）的几何平均水平显著升高（S, sonnei, 0.32-8.25 ELISA单位[EU]； S. flexneri 2a, 1.15-20.5 EU, P < 0.0001），第6周再次接种可诱导对S. flexneri 2a LPS的增强应答（20.5-30.5 EU, P = 0.003）。6个月后，两组Ige抗lps几何平均水平均高于接种前水平（P < 0.0001）。IgM和IgA抗lps的升高幅度较小。研究中的志贺氏菌结合物在儿童中是安全的，具有免疫原性，值得对其有效性进行评估。
O-specific polysaccharide conjugates of shigellae were safe and immunogenic in young adults, and a Shigella sonnei conjugate conferred protection [1-3], Shigellosis is primarily a disease of children; therefore, the safety and immunogenicity of S. sonnei and Shigella flexneri 2a conjugates were studied in 4- to 7-year-old children. Local and systemic reactions were minimal. The first injection of both conjugates elicited significant rises in geometric mean levels of serum IgG only to the homologous lipopolysaccharide (LPS) (S, sonnei, 0.32-8.25 ELISA units [EU]; S. flexneri 2a, 1.15-20.5 EU; P < .0001), Revaccination at 6 weeks induced a booster response to S. flexneri 2a LPS (20.5-30.5 EU, P = .003). Six months later, the geometric mean levels of Ige anti-LPS for both groups were higher than the prevaccination levels (P < .0001). Similar, but lesser, rises were observed for IgM and IgA anti-LPS, The investigational Shigella conjugates were safe and immunogenic in children and merit evaluation of their efficacy.