Adrenal medullary and cortical blood flow during hemorrhage.
Adrenal medullary and cortical blood flow during hemorrhage.
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出血时肾上腺髓质和皮质血流。
DOI：
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发表时间：
1986
影响因子：
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通讯作者：
R. Traystman
中科院分区：
文献类型：
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作者：
M. Breslow;A. Mennen;R. Koehler;R. Traystman
我们使用放射性标记微球技术来测量出血性低血压时肾上腺髓质和皮质的血流量。将20只戊巴比妥麻醉、通气的成年杂种犬流血的至加压瓶系统中，以将平均动脉血压降低并维持在100、80、60或40 mmHg（n = 5/组）。在出血前和出血后2、5、10、15和25分钟测量血流量。在所有出血水平，肾上腺髓质血流量均显著增加（100-400%）。相反，观察到皮质血流量减少（约50%），出血至80、60和40 mmHg。皮质血流量在25分钟时恢复到对照水平，40 mmHg组除外。整个肾上腺血流量显示出早期、短暂的减少，这与肾上腺皮质包括腺体的大部分这一事实一致，但它不能准确反映皮质或髓质血流量的变化。由于该测量肾上腺髓质和皮质血流量的方法是为当前实验开发的，因此对该技术进行了广泛评价（n = 31只动物）。这些研究包括证明注射4 × 10（6）个微球可在肾上腺髓质和皮质中产生足够数量的微球，从而可以估计血流量（大于或等于400个球/样品），15微米球几乎完全包埋在肾上腺中（大于98%），多次注射微球（n = 5）不会改变血流，并且在该血管床中似乎不会发生任何显着程度的微球流动。（250字处删节）
We used a radiolabeled microsphere technique to measure adrenal medullary and cortical blood flow during hemorrhagic hypotension. Twenty pentobarbital-anesthetized, ventilated, adult mongrel dogs were bled into a pressurized bottle system to reduce and maintain mean arterial blood pressure at 100, 80, 60, or 40 mmHg (n = 5/group). Blood flow was measured prior to and 2, 5, 10, 15, and 25 min posthemorrhage. Adrenal medullary blood flow increased markedly (100-400%) at all levels of hemorrhage. In contrast, decreases in cortical blood flow were observed (approximately 50%) with hemorrhage to 80, 60, and 40 mmHg. Cortical blood flow returned to control levels at 25 min, except in the 40-mmHg group. Whole adrenal gland blood flow showed early, transient decreases, consistent with the fact that the adrenal cortex comprises the bulk of the gland, but it did not precisely reflect either cortical or medullary blood flow changes. Since this method for measuring adrenal medullary and cortical blood flow was developed for the current experiment, extensive evaluation of the technique was performed (n = 31 animals). These studies included demonstration that injection of 4 X 10(6) microspheres results in sufficient numbers of microspheres in the adrenal medulla and cortex to permit estimation of blood flow (greater than or equal to 400 spheres/sample), that 15-micron spheres are almost completely entrapped in the adrenal gland (greater than 98%), that multiple injections of microspheres (n = 5) do not alter blood flow, and that streaming of microspheres does not appear to occur to any significant extent in this vascular bed.(ABSTRACT TRUNCATED AT 250 WORDS)