Association between adverse childhood experiences and brain volumes among Japanese community-dwelling older people: Findings from the NEIGE study
Association between adverse childhood experiences and brain volumes among Japanese community-dwelling older people: Findings from the NEIGE study
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DOI：
10.1016/j.chiabu.2021.105456
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发表时间：
2022-01-03
影响因子：
4.8
通讯作者：
Shobugawa, Yugo
中科院分区：
文献类型：
--
作者：
Koyama, Yuna;Fujiwara, Takeo;Shobugawa, Yugo
背景：不良童年经历（ACE）可以通过大脑结构差异影响晚年的健康结果。然而，有没有足够的经验证据表明，脑形态差异是否仍然存在，直到老迈ages.Objective：我们研究了ACE和脑容量之间的关联在老年individuals.Participants和设置：居民年龄在65-84岁，在日本十日町市，随机招募，491名参与者包括在analys.Methods：ACE进行了评估与自报问卷。通过结构磁共振imaging.Results：共143例（27.1%）参与者经历了一次ACE，33例（6.7%）经历了两次或两次以上ACE。有两个或两个以上ACE的受试者的前扣带皮质体积较大（B = 0.346，95%置信区间[CI] = 0.04至0.66），海马（B =-0.287，95% CI = -0.58至0.001）和杏仁核（B =-0.313，95% CI = -0.59至0.03）体积较小。有趣的是，我们观察到剥夺和威胁之间存在明显的联系。也就是说，剥夺与较小的杏仁核体积有关（B =-0.164，95% CI = -0.32至-0.01）和前扣带皮质体积较大的威胁（B = 0.401，95% CI = 0.11 - 0.70）。ACE与老年人负责情绪和自我调节的前扣带皮层、海马和杏仁核等脑区的体积有关。ACE对杏仁核的作用通常由剥夺经历驱动，而对前扣带皮层的作用则由威胁驱动。
Background: Adverse childhood experiences (ACEs) can affect later-life health outcomes via brain structural differences. However, there is no sufficient empirical evidence about whether brain morphological differences remain until old ages.Objective: We examined the association between ACEs and brain volumes among older individuals.Participants and setting: Residents aged 65-84 years in Tokamachi City, Japan, were randomly recruited, and 491 participants were included in the analysis.Methods: ACEs were assessed with a self-reported questionnaire. The volumes of seven brain regions of interests were evaluated via structural magnetic resonance imaging.Results: In total, 143 (27.1%) participants experienced one ACE and 33 (6.7%) two or more ACEs. Participants with two or more ACEs had a larger anterior cingulate cortex volume (B = 0.346, 95% confidence interval [CI] = 0.04 to 0.66) and smaller hippocampal (B = -0.287, 95% CI = -0.58 to 0.001) and amygdala (B = -0.313, 95% CI = -0.59 to -0.03) volumes. Interestingly, we observed a distinct association between deprivation and threat. That is, deprivation was associated with a smaller amygdala volume (B = -0.164, 95% CI = -0.32 to -0.01) and threat with a larger anterior cingulate cortex volume (B = 0.401, 95% CI = 0.11 to 0.70).Conclusions: ACEs were associated with the volumes of brain regions such as anterior cingulate cortex, hippocampus, and amygdala, which are responsible for emotion and self-regulation in older population. The effect of ACEs on the amygdala was commonly driven by deprivation experiences and that on the anterior cingulate cortex by threat.