The International Atomic Energy Agency International Doubly Labelled Water Database: Aims, Scope and Procedures
The International Atomic Energy Agency International Doubly Labelled Water Database: Aims, Scope and Procedures
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DOI：
10.1159/000503668
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Murphy-Alford, Alexia J.
中科院分区：
文献类型：
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作者：
Speakman, John R.;Pontzer, Herman;Murphy-Alford, Alexia J.
背景：双标记水（DLW）方法是一种基于同位素的技术，从氧和氢的稳定同位素的差异消除开始，在1-3周的时间内量化总能量消耗（TEE）。这种方法发明于20世纪50年代，但是由于测量低同位素浓度的能力有限，再加上同位素的高成本，这意味着它直到20世纪80年代才可以用于人类。它的使用仍然相对昂贵，而且仅靠小样本无法解决围绕能量平衡的一些重要问题，例如能量消耗如何随时间变化，以及能量消耗如何随年龄、性别和不同环境而变化。总结：通过综合不同研究的信息，这些问题的答案可能成为可能。国际原子能机构DLW数据库的建立是为了汇集多个研究的DLW数据。它由目前使用该方法的主要实验室发起，并由原子能机构主持。目前，该数据库包含来自23个国家的DLW个人的6621项TEE测量，以及研究参与者的各种附加数据。关键信息：原子能机构DLW数据库是支持未来能源需求研究的关键资源。
Background: The doubly labelled water (DLW) method is an isotope-based technique that quantifies total energy expenditure (TEE) over periods of 1-3 weeks from the differential elimination of stable isotopes of oxygen and hydrogen. The method was invented in the 1950s, but limited ability to measure low isotope enrichments combined with the high cost of isotopes meant it only became feasible to use in humans in the 1980s. It is still relatively expensive to use, and alone small samples are unable to tackle some of the important questions surrounding energy balance such as how have expenditures changed over time and how do expenditures differ with age, between sexes and in different environments? Summary: By combining information across studies, answers to such questions may be possible. The International Atomic Energy Agency (IAEA) DLW database was established to pool DLW data across multiple studies. It was initiated by the main labs currently using the method and is hosted by the IAEA. At present, the database contains 6,621 measures of TEE by DLW from individuals in 23 countries, along with various additional data on the study participants. Key Messages: The IAEA DLW database is a key resource enabling future studies of energy demands.