USE OF AN INTRAVENOUS BRANCHED-CHAIN AMINO-ACID ENRICHED DIET IN THE TUMOR-BEARING RAT
USE OF AN INTRAVENOUS BRANCHED-CHAIN AMINO-ACID ENRICHED DIET IN THE TUMOR-BEARING RAT
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DOI：
10.1007/bf02470093
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
BLACKBURN, GL
中科院分区：
文献类型：
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作者：
KAWAMURA, I;SATO, H;BLACKBURN, GL
本研究的目的是确定在不刺激恶性荷瘤动物肿瘤生长的情况下，静脉注射富集支链氨基酸（BCAA）是否会影响宿主组织中的氮潴留。植入纤维肉瘤的NEDH/c大鼠接受两种全肠外营养方案中的一种，一种是按重量计算含有25% BCAA的氨基酸配方，另一种含有50% BCAA的氨基酸配方。氮潴留在两个荷瘤组中相似，尽管比在非荷瘤动物中观察到的高出47% （p < 0.05）。25% BCAA配方的大鼠体内肿瘤的存在显著降低了骨骼蛋白合成（从10.1% /天降至6.1% /天），但50% BCAA配方的大鼠骨骼蛋白合成增加到7.9% /天。至少在本实验模型中，静脉给药强化支链氨基酸不会促进肿瘤生长并支持骨骼蛋白合成。
The purpose of this study was to determine whether a branched chain amino acids (BCAA) enriched intravenous feeding would have an effect on nitrogen retention in the host tissue, without stimulating tumor growth in the malignant tumor bearing animal. NEDH/c rats with an implanted fibrosarcoma were put on one of two total parenteral nutrition regimens, one of an amino acid formula containing 25 percent BCAA, by weight and the other containing 50 per cent BCAA. Nitrogen retention in the two tumor-bearing groups was similar, although it was 47 per cent greater than observed in the non-tumor bearing animals (p < 0.05). Skeletal protein synthesis was significantly reduced by the presence of the tumor in rats on the 25 per cent BCAA formula (from 10.1 per cent/day to 6.1 per cent/day) but was increased to 7.9 per cent/day by the 50 per cent BCAA formula. The BCAA enriched intravenous feeding does not enhance tumor growth and supports skeletal proteins synthesis, at least in this experimental model.