A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells
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DOI：
10.1038/42716
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发表时间：
1997-06-12
期刊：
影响因子：
64.8
通讯作者：
Figdor, CG
中科院分区：
文献类型：
--
作者：
Adema, GJ;Hartgers, F;Figdor, CG
树突状细胞形成高效抗原呈递细胞系统。在外周捕获抗原后，它们迁移到淋巴器官，在那里它们将抗原呈递给T细胞（1，2）。树突状细胞与初始T细胞相互作用并使其敏感的看似独特的能力使树突状细胞在免疫应答的启动中发挥核心作用，并使其能够用于对抗癌症，病毒感染和其他疾病的治疗策略。它们如何优先与幼稚T淋巴细胞而不是活化的T淋巴细胞相互作用仍然知之甚少。趋化因子在免疫监视中指导白色血细胞的运输（3，4）。在这里，我们报告的C-C趋化因子（DC-CK 1），是特异性表达的人树突状细胞在高水平的鉴定和表征。组织分布分析表明，树突状细胞中存在的生发中心和T-细胞区域的次级淋巴器官表达这种趋化因子。我们发现DC-CK 1与RANTES、MIP-1 α和白细胞介素-8相反，优先吸引初始T细胞（CD 45 RA（+））。树突状细胞在免疫应答起始位点特异性表达DC-CK 1，结合其对幼稚T细胞的趋化活性，表明DC-CK 1在诱导免疫应答中具有重要的规则。
Dendritic cells form a system of highly efficient antigen-presenting cells. After capturing antigen in the periphery, they migate to lymphoid organs where they present the antigen to T cells(1,2). Their seemingly unique ability to interact with and sensitize naive T cells gives dendritic cells a central role in the initiation of immune responses and allows them to be used in therapeutic strategies against cancer, viral infection and other diseases. How they interact preferentially with naive rather than activated T lymphocytes is still poorly understood. Chemokines direct the transport of white blood cells in immune surveillance(3,4). Here we report the identification and characterization of a C-C chemokine (DC-CK1) that is specifically expressed by human dendritic cells at high levels. Tissue distribution analysis demonstrates that dendritic cells present in germinal centres and T-cell areas of secondary lymphoid organs express this chemokine. We show that DC-CK1, in contrast to RANTES, MIP-1 alpha, and interleukin-8, preferentially attracts naive T cells (CD45RA(+)). The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC-CK1 has an important rule in the induction of immune responses.