THE EARLY HOST AND MATERIAL RESPONSE OF BONE-BONDING AND NONBONDING GLASS-CERAMIC IMPLANTS AS REVEALED BY SCANNING ELECTRON-MICROSCOPY AND HISTOCHEMISTRY
THE EARLY HOST AND MATERIAL RESPONSE OF BONE-BONDING AND NONBONDING GLASS-CERAMIC IMPLANTS AS REVEALED BY SCANNING ELECTRON-MICROSCOPY AND HISTOCHEMISTRY
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DOI：
10.1016/0142-9612(91)90076-m
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发表时间：
1991-11-01
期刊：
影响因子：
14
通讯作者：
GROSS, UM
中科院分区：
文献类型：
--
作者：
MULLERMAI, C;VOIGT, C;GROSS, UM
本文用扫描电镜和组织化学方法研究了骨结合和非结合玻璃陶瓷在大鼠股骨中的界面及其材料和宿主的反应。 在这些植入物周围的伤口愈合过程中，可以区分出四个重叠阶段：（1）血凝块形成，（2）组织形成，（3）初级骨和钙化形成，以及（4）持续数月至数年的重塑。 这种愈合顺序在含有非结合植入物的金属离子周围受到干扰，如酸性磷酸酶阳性巨噬细胞的较长沉降和材料表面的干扰钙化所示。 由于浸出和腐蚀现象，只有骨结合植入物的表面形态发生了相当大的变化。 从玻璃和陶瓷之间的相变开始，玻璃部分的优先浸出有助于产生为纤维和原纤维提供粘合点的表面隆起。 插入纤维的后续矿化有助于界面处的拉伸强度。 这些发现对于进一步理解骨结合机制和进一步开发表面活性材料至关重要。
The interface of bone-bonding and non-bonding glass-ceramics in the femur of rats with the concomitant material and host response has been investigated by scanning electron microscopy (SEM) and histochemistry after transverse fractures in the interface level. During wound healing around these implants, four overlapping phases could be distinguished: (1) blood clot formation, (2) formation of organization tissue, (3) formation of primary bone and calcification, and (4) remodelling which lasts from months to years. This sequence of healing was disturbed around metal ions containing non-bonding implants, as shown by a longer settlement of acid phosphatase positive macrophages and a disturbed calcification at the surface of the material. Only bone-bonding implants developed considerable changes in surface morphology due to leaching and corrosion phenomena. A preferential leaching of the glass moiety, starting at the phase transition between glass and ceramic, contributes to the production of surface elevations which provide adhesion points for fibres and fibrils. Subsequent mineralization of inserting fibres contributes to a tensile strength at the interface. These findings are essential for further understanding of bone-bonding mechanisms and for further development of surface-reactive materials.