On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin
On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin
复制标题
DOI：
10.1039/c2md20163a
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Sharma, Raman
中科院分区：
文献类型：
--
作者：
Mascitti, Vincent;Thuma, Benjamin A.;Sharma, Raman
本文介绍了降糖药厄图格洛津的发现。该化合物属于一类新的含二氧杂双环[3.2.1]辛烷结构的SGLT2抑制剂。本文描述了有机合成在影响我们的药物化学策略和加快我们的计划进展方面所发挥的关键作用。
The discovery of antidiabetic agent ertugliflozin is described. The compound belongs to a new class of SGLT2 inhibitors bearing a dioxa-bicyclo[3.2.1]octane motif. This article describes the critical role that organic synthesis played in both influencing our medicinal chemistry strategy and speeding up the progression of our program.