C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.
C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.
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DOI：
10.1097/qai.0b013e3181e0cdea
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发表时间：
2010-08
期刊：
影响因子：
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通讯作者：
Rakai Health Sciences Program
中科院分区：
文献类型：
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作者：
Redd AD;Eaton KP;Kong X;Laeyendecker O;Lutalo T;Wawer MJ;Gray RH;Serwadda D;Quinn TC;Rakai Health Sciences Program
微生物易位被认为是HIV-1疾病进展期间观察到的免疫激活增强的一个促成因素。在乌干达Rakai进行的HIV-1血清转换者纵向研究中，微生物易位与HIV-1疾病进展无关。然而，在这一人群中，一般免疫激活在HIV疾病进展中的作用尚未得到充分研究。对来自乌干达Rakai的三个HIV-1疾病进展组[长期无进展者（LTNP）、标准进展者（SP）和快速进展者（RP）]中HIV-1血清转换者的纵向血清样本进行了C反应蛋白（CRP）水平检测，CRP是免疫激活的标志物。CRP水平在SP组中显著升高（p<0.0001），但在RP组或LTNP组中没有。RP组在HIV血清转换后第一年的CRP水平显著高于LTNP组（p<0.05）。对于整个人群，CRP水平与脂多糖水平呈负相关（p<0.05），与内毒素抗体水平无关。这项研究表明，在这一人群中，免疫激活的增加与HIV-1疾病进展显著相关，但与微生物易位无关。
Microbial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined. Longitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation. CRP levels significantly increased in the SP group (p<0.0001), but not in the RP group or the LTNP group. CRP levels during the first year post-HIV-seroconversion in the RP group were significantly higher than those observed in the LTNP group (p<0.05). For the entire population CRP levels negatively correlated with Lipopolysaccharide levels (p<0.05) and were not associated with endotoxin antibody levels. This study suggests that in this population increased immune activation is significantly associated with HIV-1 disease progression, but not microbial translocation.