Molecular Pathways: Regulation of Metabolism by RB
Molecular Pathways: Regulation of Metabolism by RB
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DOI：
10.1158/1078-0432.ccr-11-3164
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发表时间：
2012-11-15
影响因子：
11.5
通讯作者：
Chesney, Jason
中科院分区：
文献类型：
--
作者：
Clem, Brian F.;Chesney, Jason
视网膜母细胞瘤 (RB-1) 基因作为一种肿瘤抑制基因，在大多数人类癌症中通过直接或间接的基因改变而被破坏，这一发现引起了人们对其功能和下游效应子的兴趣增加。尽管将这种肿瘤抑制因子与人类癌症联系起来的经典途径详细说明了它与 E2F 转录因子和细胞周期进展的相互作用，但最近的研究表明 RB-1 在抑制糖酵解和谷氨酰胺分解代谢中发挥着重要作用。 RB-E2F 轴抑制的精确代谢转运蛋白和酶的表征应该能够鉴定具有选择性和有效抗肿瘤特性的小分子拮抗剂。临床癌症研究； 18（22）； 6096-100。 (C)2012 AACR。
The discovery of the retinoblastoma (RB-1) gene as a tumor suppressor that is disrupted in a majority of human cancers either via direct or indirect genetic alterations has resulted in increased interest in its functions and downstream effectors. Although the canonical pathway that links this tumor suppressor to human cancers details its interaction with the E2F transcription factors and cell-cycle progression, recent studies have shown an essential role for RB-1 in the suppression of glycolytic and glutaminolytic metabolism. Characterization of the precise metabolic transporters and enzymes suppressed by the RB-E2F axis should enable the identification of small molecule antagonists that have selective and potent antitumor properties. Clin Cancer Res; 18(22); 6096-100. (C)2012 AACR.