Tumor necrosis factor-alpha and the cytokine network in psoriasis
Tumor necrosis factor-alpha and the cytokine network in psoriasis
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DOI：
10.1590/s0365-05962012000500001
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发表时间：
2012-10-01
影响因子：
1.7
通讯作者：
Carneiro, Sueli Coelho da Silva
中科院分区：
文献类型：
--
作者：
Brotas, Arles Martins;Cunha, José Marcos Tellas;Carneiro, Sueli Coelho da Silva
新的分子研究方法极大地扩展了细胞因子在包括牛皮癣在内的几种疾病中的作用。这些多肽协调的工作是居留的炎症细胞(角质形成细胞和内皮细胞)和浸润性细胞(中性粒细胞、淋巴细胞、朗格汉斯细胞)之间的通信必不可少的。这是一个复杂的网络，由于冗余、协同作用，有时还存在细胞因子的拮抗作用，这阻碍了对疾病发病机制的充分了解。目前，试图确定一个主要参与者似乎还为时过早，但正如我们将看到的那样，肿瘤坏死因子-α参与了银屑病斑块发展的所有阶段。
New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans cells). This is a complex network due to redundancy, synergism and, sometimes, the antagonism of cytokines, which prevents full understanding of the pathogenesis of the disease. Currently, it seems premature to try to establish a main actor, but TNF-alpha participates in all stages of psoriatic plaque development, as we shall see.