Effects of increased ventilation on lung lymph flow in unanesthetized sheep.
Effects of increased ventilation on lung lymph flow in unanesthetized sheep.
复制标题
增加通气量对未麻醉绵羊肺淋巴流量的影响。
DOI：
10.1152/jappl.1986.60.6.2063
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Fishman,AP
中科院分区：
文献类型：
--
作者：
Albelda,SM;Hansen-Flaschen,JH;Lanken,PN;Fishman,AP
为了确定自发分钟通气增加对肺液平衡的影响，我们在6只气管切开、未麻醉、自发呼吸的羊的呼吸回路中增加了外部死腔，这些羊的肺淋巴瘘是手术造成的。120-180 ml死腔的增加导致分钟通气量增加50-100%（继发于潮气量和频率的增加），而肺动脉压、肺毛细血管楔形压、心输出量或动脉血气张力未发生变化。自发通气的增加与肺淋巴流量平均增加27% （P < 0.05）和总蛋白淋巴与血浆浓度比（L/P）平均降低11% （P < 0.05）相关。呼吸急促2 ~ 3 h后，淋巴流量和总蛋白的L/P接近稳定值，且淋巴流量的增加持续至少18 h的死腔呼吸。清除死腔与淋巴流迅速恢复到基线水平（在45分钟内）有关。这些结果表明，呼吸急促会增加肺经血管滤过率。由于没有观察到血管压力或心输出量的变化，这种血管滤过的增加很可能是由于间质液压力的下降。
To determine the effect of an increase in spontaneous minute ventilation on lung fluid balance, we added external dead space to the breathing circuit of six tracheostomized, unanesthetized, spontaneously breathing sheep in which lung lymph fistulas had been created surgically. The addition of 120–180 ml of dead space caused minute ventilation to increase by 50–100% (secondary to increases in both tidal volume and frequency), without changing pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac output, or arterial blood gas tensions. The increase in spontaneous ventilation was associated with an average increase of 27% in lung lymph flow (P less than 0.05) and an average reduction of 11% in the lymph-to-plasma concentration ratio (L/P) for total protein (P less than 0.05). Lymph flow and L/P for total protein approached stable values after 2–3 h of hyperpnea, and the increase in lymph flow persisted for at least 18 h of dead-space breathing. Removal of dead space was associated with a rapid return (within 45 min) of lymph flow to base-line levels. These results suggest that hyperpnea increases the pulmonary transvascular filtration rate. Since no changes in vascular pressures or cardiac output were observed, this increase in transvascular filtration is most likely due to a fall in interstitial fluid pressure.