Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans.
Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans.
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性别偏向表达与黑腹果蝇和拟果蝇中的染色质状态相关。
DOI：
10.1101/2023.01.13.523946
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
McIntyre,LaurenM
中科院分区：
文献类型：
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作者：
Nanni,AdalenaV;Martinez,Natalie;Graze,Rita;Morse,Alison;Newman,JeremyRB;Jain,Vaibhav;Vlaho,Srna;Signor,Sarah;Nuzhdin,SergeyV;Renne,Rolf;McIntyre,LaurenM
我们提出了一个新的模型的染色质状态和性别偏见的表达协会。我们假设开放染色质在性别中富集，我们看到表达偏倚（OS）和异性（CO）中的闭合染色质。本研究对D. melanogaster和D.在simulans头部组织中，表达的性别偏好与H3 K4 me 3（开放标记）相关，在两个物种中，雄性偏好基因在雄性中，雌性偏好基因在雌性中。性别偏见的表达也在很大程度上保守的方向和幅度之间的两个物种的X和常染色体。在雄性偏向的直系同源物中，如果两个物种在雌性中都有H3 K27 me 2 me 3标记，则物种之间的性别偏向比与当任一物种或两个物种在雌性中都没有H3 K27 me 2 me 3时相比更加不同。雌性H3 K27 me 2 me 3标记在两个物种的常染色体上与雄性偏好表达相关，但仅在D.黑腹菌在女性偏向的直系同源物中，无论男性中的H3 K27 me 2 me 3标记如何，性别偏向比率的物种之间的关系都是相似的。女性偏向的直向同源物在性别偏向的比率上比男性偏向的直向同源物更相似，并且在获得/失去性别偏向的直向同源物中的表达中存在过量的男性偏向。在这两个物种中，性别限制表达都存在过度的雄性偏好，这表明过度的雄性偏好是由于物种之间的快速进化。与常染色体相比，X染色体在这两个物种中都富集了雄性限制性H3 K4 me 3，并且在表达中富集了性别偏倚。
We propose a new model for the association of chromatin state and sex-bias in expression. We hypothesize enrichment of open chromatin in the sex where we see expression bias (OS) and closed chromatin in the opposite sex (CO). In this study of D. melanogaster and D. simulans head tissue, sex-bias in expression is associated with H3K4me3 (open mark) in males for male-biased genes and in females for female-biased genes in both species. Sex-bias in expression is also largely conserved in direction and magnitude between the two species on the X and autosomes. In male-biased orthologs, the sex-bias ratio is more divergent between species if both species have H3K27me2me3 marks in females compared to when either or neither species has H3K27me2me3 in females. H3K27me2me3 marks in females are associated with male-bias in expression on the autosomes in both species, but on the X only in D. melanogaster. In female-biased orthologs the relationship between the species for the sex-bias ratio is similar regardless of the H3K27me2me3 marks in males. Female-biased orthologs are more similar in the ratio of sex-bias than male-biased orthologs and there is an excess of male-bias in expression in orthologs that gain/lose sex-bias. There is an excess of male-bias in sex-limited expression in both species suggesting excess male-bias is due to rapid evolution between the species. The X chromosome has an enrichment in male-limited H3K4me3 in both species and an enrichment of sex-bias in expression compared to the autosomes.