Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial
Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial
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DOI：
10.1155/2018/5461436
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Gratteri, Santo
中科院分区：
文献类型：
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作者：
Di Renzo, Laura;Cioccoloni, Giorgia;Gratteri, Santo
背景。非传染性疾病（NCD）是全球第一大死亡原因。地中海饮食可能在预防非传染性疾病方面发挥着至关重要的作用，而这种饮食中葡萄酒的存在可能对健康发挥积极作用。方法。 54 名健康志愿者饮用以下饮料之一：红葡萄酒 (RW) 或白葡萄酒 (WW)、伏特加 (VDK) 和/或地中海餐 (MeDM) 和高脂餐 (HFM)。结果。 OxLDL-C 在基线与 HFM、MeDM 与 HFM 以及 HFM 与 HFM + RW 之间发生显着变化 (p < 0·05)。仅在 RW 后观察到过氧化氢酶 (CAT) 显着上调。相反，WW、VDK、RW + MeDM、HF + WW 和 HF + VDK 确定了 CAT 基因的显着下调。超氧化物歧化酶 2 (SOD2) 基因表达在 WW、MeDM + VDK 和 RW 中上调。相反，HFM + VDK 确定其表达下调。 RW、RW + MeDM 和 RW + HFM 导致谷胱甘肽过氧化物酶-1 (GPX1) 上调。结论。我们的研究结果表明，低/适量摄入酒精饮料（经营养保健品证明有效）以及乙醇与地中海饮食的关联，可以通过积极调节抗氧化基因表达来降低动脉粥样硬化的发病风险，从而帮助预防炎症和氧化损伤。
Background. Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health. Methods. 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM). Results. OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p < 0 05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gene. Superoxide dismutase 2 (SOD2) gene expression was upregulated in WW, MeDM + VDK, and RW. Contrariwise, HFM + VDK determined a downregulation of its expression. RW, RW + MeDM, and RW + HFM caused the upregulation of glutathione peroxidase-1 (GPX1). Conclusions. Our results suggest that the association of low/moderate intake of alcohol beverages, with nutraceutical-proven effectiveness, and ethanol, in association with a Mediterranean diet, could determine a reduction of atherosclerosis risk onset through a positive modulation of antioxidant gene expression helping in the prevention of inflammatory and oxidative damages.