Disseminated Bacillus CalmetteGuerin Infection after BCG Vaccination
Disseminated Bacillus CalmetteGuerin Infection after BCG Vaccination
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DOI：
10.1093/tropej/fmn053
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发表时间：
2008-12-01
影响因子：
2
通讯作者：
Parvaneh, Nima
中科院分区：
文献类型：
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作者：
Rezai, Mohammad Sadegh;Khotaei, Ghamartaj;Parvaneh, Nima
在伊朗，所有新生儿出生时都要接种卡介苗。卡介苗的全身不良反应如骨髓炎和播散性卡介苗感染是罕见的。这是一项回顾性研究，15例72个月的病人入院与全身综合征兼容的播散性分枝杆菌病在2004年7月。播散性卡介苗病发生在8名小于6个月的儿童和12名小于12个月的患者中。12例患者为男性。15例患者中有9例患有已知的原发性免疫缺陷疾病，包括严重联合免疫缺陷、慢性肉芽肿病、细胞介导的免疫缺陷和HIV感染。9例（60例）对4种抗分枝杆菌药物治疗和干扰素γ治疗有良好反应。播散性BCG疾病是BCG疫苗接种的一种罕见但破坏性的并发症，应在适当的临床环境中予以考虑。严重免疫缺陷的婴儿风险最大，他们对标准疗法的反应很差。
The BCG is administered to all the newborns at birth in Iran. Systemic adverse reactions to BCG vaccine such as osteomyelitis and disseminated BCG infection are rare. This is a retrospective study of 15 cases 72 months who were admitted with systemic syndrome compatible with disseminated mycobacterial disease during 200407. Disseminated BCG disease occurred in eight children younger than 6-months old and 12 patient younger than 12-months old. Twelve patients were male. Nine of 15 patients had well known primary immune deficiency disorders including severe combined immunodeficiency, chronic granulomatous disease; cell mediated immune defect and HIV infection. Nine (60) cases had good response to four anti-mycobacterial drug therapy and interferon gamma. Disseminated BCG disease is a rare but devastating complication of BCG vaccination that should be considered in the appropriate clinical setting. Severe immune-compromised infants are at greatest risk and they respond poorly to standard therapies.