In vitro characterization of atherosclerotic carotid plaque with multidetector computed tomography and histopathological correlation
In vitro characterization of atherosclerotic carotid plaque with multidetector computed tomography and histopathological correlation
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DOI：
10.1007/s00330-005-2712-2
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发表时间：
2005-09-01
影响因子：
5.9
通讯作者：
van der Lugt, A
中科院分区：
文献类型：
--
作者：
de Weert, TT;Ouhlous, M;van der Lugt, A
本体外研究以组织学为金标准，评价了16层多排计算机断层扫描（MDCT）在评估颈动脉斑块成分中的性能。对21例标本进行了扫描和重建。从每个标本中选择三个相应的MDCT图像和组织切片。评估主要斑块成分（钙化、纤维组织和脂质）的Hounsfield值（HV）。将MDCT评估的斑块面积（mm 2）与组织学分析结果进行比较。140 kVp值和中间重建算法是最佳方案。在21个标本中，有15个可以将MDCT图像与组织学匹配。钙化、纤维组织和脂质的HV分别为45 +/- 21、79 +/- 20和960 +/- 491 HU（P< 0.001）。比较27个匹配节段的斑块面积。MDCT和组织学上的钙化和脂质区域相关性良好（分别为R-2 = 0.83和R-2 = 0.68）。脂质面积的平均差异为0.1 mm（2）（95% CI = - 2.1 - 2.3 mm（2））。这项体外研究表明，MDCT能够表征和量化动脉粥样硬化斑块的富脂部分。
This in vitro study evaluated the performance of 16-slice multidetector computed tomography (MDCT) in the assessment of carotid plaque components, with histology as the gold standard. Twenty-one specimens ( n= 21) were scanned and reconstructed after optimization of the protocol. Three corresponding MDCT images and histologic sections were selected from each specimen. The Hounsfield values (HV) of the major plaque components ( calcifications, fibrous tissue and lipid) were assessed. Plaque areas (mm(2)) assessed with MDCT were compared with the results from histologic analysis. A value of 140 kVp and an intermediate reconstruction algorithm was the optimal protocol. In 15 out of 21 specimens it was possible to match MDCT images with histology. The HV of calcifications, fibrous tissue and lipid were 45 +/- 21, 79 +/- 20 and 960 +/- 491 HU ( P< 0.001), respectively. Plaque areas were compared in 27 matched levels. The calcified and lipid areas on MDCT and histology correlate well ( R-2 = 0.83 and R-2 = 0.68, respectively). The mean difference in lipid area was 0.1 mm(2) (95% CI = - 2.1 - 2.3 mm(2)). This in vitro study showed that MDCT is capable of characterizing and quantifying the lipid rich portion of the atherosclerotic plaque.