Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.
Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.
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发表时间：
1996-09
期刊：
影响因子：
4.6
通讯作者：
Deborah J. Phippard;Stephen J. Weber-Hall;Paul T. Sharpe;M. Naylor;H. Jayatalake;Richard L. Maas;Ian Woo;Desmond Roberts-Clark;Philippa H. Francis-West;Yi-Hsin Liu;Robert E. Maxson;Robert E. Hill;Trevor C. Dale
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作者：
Deborah J. Phippard;Stephen J. Weber-Hall;Paul T. Sharpe;M. Naylor;H. Jayatalake;Richard L. Maas;Ian Woo;Desmond Roberts-Clark;Philippa H. Francis-West;Yi-Hsin Liu;Robert E. Maxson;Robert E. Hill;Trevor C. Dale
MSX-1和MSX-2同源框基因的表达已被证明与BMP-2和BMP-4配体在各种发育组织中协同调节。在这里，我们报告了所有四个基因的转录本在胎儿和出生后的乳腺发育过程中都受到发育调节。BMP和MSX表达的位置和时间进程表明MSX和BMP基因产物在控制上皮-间充质相互作用中发挥作用。卵巢切除后，MCF-7乳腺癌细胞中MSX-2的表达减少，而MSX-1、BMP-2和BMP-4的表达无明显变化，而人MSX-2同源物的表达受17β-雌二醇的调节。雌激素对MSX-2表达的调节增加了荷尔蒙对乳腺发育的调节通过控制上皮-间充质相互作用的可能性。
Expression of the Msx-1 and Msx-2 homeobox genes have been shown to be coordinately regulated with the Bmp-2 and Bmp-4 ligands in a variety of developing tissues. Here we report that transcripts from all four genes are developmentally regulated during both foetal and postnatal mammary gland development. The location and time-course of the Bmp and Msx expression point to a role for Msx and Bmp gene products in the control of epithelial-mesenchymal interactions. Expression of Msx-2, but not Msx-1, Bmp-2 or Bmp-4 was decreased following ovariectomy, while expression of the human Msx-2 homologue was regulated by 17beta-oestradiol in the MCF-7 breast cancer cell line. The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions.