Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences
Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences
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DOI：
10.4269/ajtmh.2007.77.910
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发表时间：
2007-11-01
影响因子：
3.3
通讯作者：
Srikiatkhachorn, Anon
中科院分区：
文献类型：
--
作者：
Gibbons, Robert V.;Kalanarooj, Siripen;Srikiatkhachorn, Anon
对单一登革病毒（DENV）感染的免疫力不提供对后续感染的异源免疫力。事实上，登革出血热（DHF）的最大风险是第二次DENV血清型暴露。相对于第一次或第二次暴露，第三次或第四次登革热感染的DHF风险尚不清楚。对我们的数据库进行的分析显示，由第三次或第四次登革病毒感染引起的登革入院人数极低（0.08-0.8%）。一旦入院，DHF相对于登革热的风险对于经历第三次或第四次DENV感染的人与经历第二次DENV感染的人没有区别。我们记录了导致DHF为1-4、2-3、3-1和3-4的新登革热血清型感染序列。
Immunity to a single dengue virus (DENV) infection does not provide heterologous immunity to subsequent infection. In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with a second DENV serotype exposure. The risk for DHF with a third or fourth dengue infection relative to a first or second exposure is not known. An analysis of our database of children admitted to the Queen Sirikit National Institute of Child Health and Kamphaeng Phet Provincial Hospital with suspected dengue illness revealed that the number of dengue admissions caused by a third or fourth DENV infection was extremely low (0.08-0.8%). Once admitted, the risk for DHF relative to dengue fever was not different for those experiencing third or fourth DENV infections over those experiencing a second DENV infection. We document new dengue serotype infection sequences leading to DHF of 1-4, 2-3, 3-1, and 3-4.