Restriction endonuclease map of endogenous mouse mammary tumor virus loci in GR, DBA, and NFS mice.
Restriction endonuclease map of endogenous mouse mammary tumor virus loci in GR, DBA, and NFS mice.
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GR、DBA 和 NFS 小鼠内源性小鼠乳腺肿瘤病毒位点的限制性核酸内切酶图谱。
DOI：
10.1016/0042-6822(86)90421-6
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发表时间：
1986
期刊：
影响因子：
3.7
通讯作者：
V. Morris
中科院分区：
文献类型：
--
作者：
D. Gray;E. Chan;J. MacInnes;V. Morris
小鼠乳腺肿瘤病毒（MMTV）作为内源性前病毒整合在大多数小鼠的基因组中。其中两个前病毒基因座（Mtv-1和Mtv-2）与病毒表达和致瘤性有关。我们制备了两个株系DBA和GR的内源性MMTV前病毒的限制性内切酶图谱，其中含有Mtv-1和Mtv-2基因座，以及第三个株系NFS，其具有低乳腺肿瘤发病率。我们发现，所有这些小鼠品系具有某些共同的MMTV基因座，即使它们的起源是大相径庭。我们还发现，一些整合的MMTV前病毒似乎已经经历了改变或缺失相比，MMTV外源前病毒DNA。因此，我们在这些小鼠品系MMTV基因座，这可以作为一个基础，为研究它们的表达差异进行了全面的表征。
Mouse mammary tumor virus (MMTV) is integrated in the genome of most mice as an endogenous provirus. Two of these MMTV proviral loci (Mtv-1andMtv-2) are associated with virus expression and tumorigenicity. We prepared restriction endonuclease maps of the endogenous MMTV proviruses in two strains, DBA and GR, which contain theMtv-1andMtv-2loci, plus a third strain, NFS, which has a low mammary tumor incidence. We find that all these mouse strains have certain MMTV loci in common even though their origins are widely divergent. We also find that some integrated MMTV proviruses appear to have undergone alterations or deletions when compared with MMTV exogenous proviral DNA. We have thus made a comprehensive characterization of MMTV loci in these mouse strains which could serve as a basis for the study of their differences in expression.
C3Hf/Ki 小鼠乳腺肿瘤发生：生发小鼠乳腺肿瘤病毒和 int-1 和 int-2 推定原癌基因的检查。
影响因子：
5
作者：
Popko,BJ;Pauley,RJ
通讯作者：
Pauley,RJ
小鼠乳腺肿瘤病毒的分子遗传学。
影响因子：
--
作者：
Traina-Dorge,V;Cohen,JC
通讯作者：
Cohen,JC