A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males.
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DAB2IP/AIP1 的一个常见遗传变异 (97906C>A) 与中国男性肺癌风险增加和早发相关。
DOI：
10.1371/journal.pone.0026944
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Yang L;Li Y;Ling X;Liu L;Liu B;Xu K;Bin X;Ji W;Lu J
DOC-2/DAB2 interactive protein (DAB2IP) is a novel identified tumor suppressor gene that inhibits cell growth and facilitates cell apoptosis. One genetic variant in DAB2IP gene was reported to be associated with an increased risk of aggressive prostate cancer recently. Since DAB2IP involves in the development of lung cancer and low expression of DAB2IP are observed in lung cancer, we hypothesized that the variations in DAB2IP gene can increase the genetic susceptibility to lung cancer. In a case-control study of 1056 lung cancer cases and 1056 sex and age frequency-matched cancer-free controls, we investigated the association between two common polymorphisms in DAB2IP gene (−1420T>G, rs7042542; 97906C>A, rs1571801) and the risk of lung cancer. We found that compared with the 97906CC genotypes, carriers of variant genotypes (97906AC+AA) had a significant increased risk of lung cancer (adjusted odds ratio [OR] = 1.33, 95%CI = 1.04–1.70, P = 0.023) and the number of variant (risk) allele worked in a dose-response manner (P trend = 0.0158). Further stratification analysis showed that the risk association was more pronounced in subjects aged less than 60 years old, males, non-smokers, non-drinkers, overweight groups and in those with family cancer history in first or second-degree relatives, and the 97906A interacted with overweight on lung cancer risk. We further found the number of risk alleles (97906A allele) were negatively correlated with early diagnosis age of lung cancer in male patients (P = 0.003). However, no significant association was observed on the −1420T>G polymorphism. Our data suggested that the 97906A variant genotypes are associated with the increased risk and early onset of lung cancer, particularly in males.
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影响因子：
7.1
作者：
JENKINS, DJA;WOLEVER, TMS;LITTLE, JA
通讯作者：
LITTLE, JA
影响因子：
6.4
作者：
Liao, Xiaoyun;Siu, Michelle Kwan-Yee;Cheung, Annie Nga-Yin
通讯作者：
Cheung, Annie Nga-Yin
影响因子：
5.8
作者：
Isidori, AM;Caprio, M;Fabbri, A
通讯作者：
Fabbri, A
影响因子：
10.3
作者：
Spitz, Margaret R.;Hong, Waun Ki;Etzel, Carol J.
通讯作者：
Etzel, Carol J.
DOI：
10.1073/pnas.0908458106
发表时间：
2009-11-24
影响因子：
11.1
作者：
Xie, Daxing;Gore, Crystal;Hsieh, Jer-Tsong
通讯作者：
Hsieh, Jer-Tsong