Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients
Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients
复制标题
免疫功能正常患者原发性中枢神经系统淋巴瘤的影像学特征（CT、MRI、MRS 和 PET/CT）
DOI：
10.1007/s10072-018-3669-7
复制
发表时间：
2019-03-01
影响因子：
3.3
通讯作者：
Zhang, Jianning
中科院分区：
文献类型：
--
作者：
Cheng, Gang;Zhang, Jianning
背景由于原发性中枢神经系统淋巴瘤（PCNSL）在非HIV感染者中发病率低，缺乏特异性临床表现和辅助检查，目的分析非小细胞肺癌原发性淋巴结转移（PCNSL）的影像学特点，方法：这是一项回顾性研究，研究对象为2001年1月至2011年12月在海军总医院接受治疗的PCNSL患者。（中国北京）。所有纳入的患者均经病理诊断为PCNSL。通过立体定向活检获得标本，并通过病理检查进行诊断。结果在118例患者中，男性73例（61.9%），女性45例（38.1%）。中位年龄为54岁（范围11-83岁）。所有患者均为B细胞淋巴瘤。病灶在计算机断层扫描（CT）图像上呈稍高信号影，在磁共振成像（MRI）上呈T1高信号和等或高T2信号。增强扫描多数病灶呈斑片状强化，部分病灶增强MRI上有特征性的“蝴蝶征”。PCNSL的磁共振波谱表现为Cho峰增高，NAA峰中度降低，Cr峰轻度降低。结论MRI对PCNSL的诊断有重要价值。了解PCNSL的影像学特征有助于提高临床诊断水平。
BackgroundBecause of the low incidence of primary central nervous system lymphoma (PCNSL) in non-HIV individuals and because of the lack of specific clinical manifestations and auxiliary examinations, the disease is easily missed or misdiagnosed.ObjectiveTo analyze the imaging features of PCNSL in non-HIV patients.MethodsThis was a retrospective study of patients with PCNSL treated between January 2001 and December 2011 at the Naval General Hospital (Beijing, China). All included patients were pathologically diagnosed with PCNSL. Specimens were obtained by stereotactic biopsy and diagnosed by pathological examination. Serological panel had to be negative for HIV.ResultsOut of the 118 patients, 73 (61.9%) were male and 45 (38.1%) were female. Median age was 54 (range 11–83) years. All patients had B cell lymphoma. The lesions showed slightly hyperintense shadows on computed tomography (CT) images, and mostly hyperintense T1 and iso- or hyperintense T2 signals on magnetic resonance imaging (MRI). Most lesions showed patchy enhancement after enhanced scanning, and some had the characteristic “butterfly sign” on enhanced MRI. The magnetic resonance spectroscopy of PCNSL manifested as increased Cho peak, moderately decreased NAA peak, and slightly decreased Cr peak. Positron emission computed tomography indicated high metabolism of18F-FDG in PCNSL lesions.ConclusionMRI is important in the diagnosis of PCNSL. Understanding the imaging features of PCNSL will help improve its diagnosis in clinics.