HYPERGLYCEMIA-INDUCED HYPONATREMIA - CALCULATION OF EXPECTED SERUM SODIUM DEPRESSION
HYPERGLYCEMIA-INDUCED HYPONATREMIA - CALCULATION OF EXPECTED SERUM SODIUM DEPRESSION
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DOI：
10.1056/nejm197310182891607
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发表时间：
1973-01-01
影响因子：
158.5
通讯作者：
KATZ, MA
中科院分区：
文献类型：
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作者：
KATZ, MA
至少1/4世纪以来，临床医生已经认识到高血糖会降低血清钠浓度。由于葡萄糖主要存在于细胞外液体中，其浓度的增加会使细胞外的水分流失，导致细胞外溶质的稀释。对于给定的葡萄糖水平，评估预期的钠减少是有用的，因为偏离这样的预测值可以确定低钠血症或高钠血症的诊断，这可能需要在纠正高血糖的同时进行治疗。大多数临床医生使用经验法则，即每100毫克/盎司，血清钠每升降低2.8 mEq。
FOR at least 1/4 century clinicians have recognized that hyperglycemia depresses serum sodium concentration.1Since glucose is largely restricted to extracellular fluid, an increase in its concentration moves water out of cells, causing dilution of extracellular solute. It is useful to assess the expected sodium decrease for a given glucose level, because deviations from such a predicted value establish the diagnosis of hyponatremia or hypernatremia that may require therapy in addition to correction of the hyperglycemia. Most clinicians use the rule of thumb that there is a 2.8 mEq per liter decrease in serum sodium for every 100 mg per . . .