The balance of Th1/Th2 cytokines in rheumatoid arthritis
The balance of Th1/Th2 cytokines in rheumatoid arthritis
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DOI：
10.1053/berh.2001.0187
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发表时间：
2001-12-01
影响因子：
5.2
通讯作者：
Kalden, JK
中科院分区：
文献类型：
--
作者：
Schulze-Koops, H;Kalden, JK
有人认为类风湿性炎症是由激活的促炎 T 辅助细胞 1 型细胞介导的。相比之下，免疫调节性 T 辅助 2 型细胞及其细胞因子，特别是白细胞介素 4，却很少被发现。本章回顾了 Th1/Th2 二分法的概念，并总结了 T 辅助细胞亚群标志性细胞因子的功能。我们讨论了关于 Th1/Th2 范式的类风湿性关节炎及其相关动物模型（胶原诱导的关节炎）的免疫发病机制的当前知识。越来越多的证据表明 1 型辅助性 T 驱动炎症及其对未来治疗的影响。
It has been suggested that rheumatoid inflammation is mediated by activated pro-inflammatory T helper type 1 cells. In contrast, immunomodulatory T helper type 2 cells and their cytokines, in particular interleukin-4, are rarely found. This chapter reviews the concept of the Th1/Th2 dichotomy and summarizes the functions of the signature cytokines of the T helper subsets. We discuss current knowledge of the immunopathogenesis of rheumatoid arthritis and its related animal model, collagen induced arthritis, with regard to the Th1/Th2 paradigm. The accumulating evidence for a T helper type 1 driven inflammation and the implications for future therapy are delineated.