Status Epilepticus after Prolonged Umbilical Cord Occlusion Is Associated with Greater Neural Injury Fetal Sheep at Term-Equivalent
Status Epilepticus after Prolonged Umbilical Cord Occlusion Is Associated with Greater Neural Injury Fetal Sheep at Term-Equivalent
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DOI：
10.1371/journal.pone.0096530
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发表时间：
2014-05-05
期刊：
影响因子：
3.7
通讯作者：
Gunn, Alistair J.
中科院分区：
文献类型：
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作者：
Drury, Paul P.;Davidson, Joanne O.;Gunn, Alistair J.
大多数关于缺氧缺血性脑病的临床前研究要么集中在相对轻微的损伤上，要么集中在脑缺血或缺氧缺血/低血压的功能范式上。令人惊讶的是，关于对单一的、严重的“生理”侮辱的反应的信息很少。在这项研究中，我们研究了长时间脐带阻断（UCO）后神经损伤的演变和模式。36只胎龄为125 ~ 129天（足月147天）的长期仪器化胎羊进行任意一种UCO，直到平均动脉压为
The majority of pre-clinical studies of hypoxic-ischemic encephalopathy at term-equivalent have focused on either relatively mild insults, or on functional paradigms of cerebral ischemia or hypoxia-ischemia/hypotension. There is surprisingly little information on the responses to single, severe 'physiological' insults. In this study we examined the evolution and pattern of neural injury after prolonged umbilical cord occlusion (UCO). 36 chronically instrumented fetal sheep at 125-129 days gestational age (term = 147 days) were subjected to either UCO until mean arterial pressure was