Adiponectin relationship with lipid metabolism is independent of body fat mass:: Evidence from both cross-sectional and intervention studies
Adiponectin relationship with lipid metabolism is independent of body fat mass:: Evidence from both cross-sectional and intervention studies
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DOI：
10.1210/jc.2003-031777
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Frittitta, L
中科院分区：
文献类型：
--
作者：
Baratta, R;Amato, S;Frittitta, L
脂联素影响胰岛素敏感性和脂质代谢，但这些影响是否与脂肪质量或分布相关尚不清楚。我们通过横断面研究研究了血浆脂联素和瘦素水平、胰岛素敏感性和血脂之间的关系（n = 242例受试者）和干预研究（242例中的95例），以评估体重减轻（WL）的效果。（n = 107）和肥胖（n = 135）组，血浆脂联素，而不是血浆瘦素，（P < 0.01）与胰岛素敏感性[稳态模型评估胰岛素抵抗指数（HOMA（IR））、口服葡萄糖耐量试验胰岛素敏感性指数（ISI）、242人中有115人的胆固醇、高密度脂蛋白胆固醇和甘油三酯。在校正年龄、性别、体重指数（BMI）和ISI后，这些关系仍然显著（P < 0.01）。WL后（-16.8 +/-0.8%），血浆脂联素升高，血浆瘦素降低（均P < 0.0001）。其变化（Delta）与Delta-BMI显著相关（P < 0.05）。δ-脂联素与δ-高密度脂蛋白胆固醇和δ-甘油三酯显著相关（P < 0.001），而与δ-瘦素无关;这些相关性与年龄、性别、δ-BMI和δ-ISI无关（P < 0.005）。总之，横断面和干预研究均表明血浆脂联素水平与血脂相关，而与脂肪质量无关。干预研究还表明，WL后脂联素增加与血脂改善相关，独立于胰岛素敏感性变化。
Adiponectin influences insulin sensitivity and lipid metabolism, but it is not clear whether these effects are correlated with fat mass or distribution. We studied the relationship between plasma adiponectin and leptin levels, insulin sensitivity, and serum lipids by a cross-sectional study ( n = 242 subjects) and by an intervention study ( 95 of 242) to evaluate the effect of weight loss (WL).Considering all subjects both together and subdivided into nonobese ( n = 107) and obese ( n = 135) groups, plasma adiponectin, but not plasma leptin, was significantly ( P < 0.01) correlated with insulin sensitivity [homeostasis model assessment of insulin-resistance index(HOMA(IR)), insulin sensitivity index (ISI) at oral glucose tolerance test, and clamp in 115 of 242 individuals], high-density lipoprotein cholesterol, and triglycerides. These relationships were still significant ( P < 0.01) after adjusting for age, gender, body mass index (BMI), and ISI. After WL ( - 16.8 +/- 0.8%), plasma adiponectin increased, and plasma leptin decreased ( P < 0.0001 for both). Their changes (Delta) were significantly correlated with Delta-BMI ( P < 0.05 for both). Delta-Adiponectin, but not Delta-leptin, significantly ( P < 0.001) correlated with Delta-high-density lipoprotein cholesterol and Delta-triglycerides; these correlations were independent of age, gender, Delta-BMI, and Delta-ISI ( P < 0.005). In conclusion, both cross-sectional and intervention studies indicate that plasma adiponectin level correlates with serum lipids independently of fat mass. The intervention study also suggests that adiponectin increase after WL is correlated with serum lipid improvement independently of insulin sensitivity changes.