Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms
Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms
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DOI：
10.1073/pnas.97.16.8789
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发表时间：
2000-08-01
影响因子：
11.1
通讯作者：
Greenberg, EP
中科院分区：
文献类型：
--
作者：
Parsek, MR;Greenberg, EP
细菌基因表达研究的最新进展使人们认识到，细胞间的交流和群落行为对于与高等生物的成功相互作用至关重要。种特异性的细胞间通讯参与了多种细菌与植物和动物宿主的成功致病或共生相互作用。一种类型的细胞-细胞信号传导是革兰氏阴性菌中的酰基高丝氨酸内酯群体感应。这种群体感应代表了一种专用的通信系统，使给定的物种能够在宿主中达到临界人口密度时进行感知，并通过激活宿主中持续成功所需的基因表达来做出反应。机会致病菌铜绿假单胞菌中的酰基高丝氨酸内酯信号传导是群体感应、致病性和群落行为之间关系的模型。在铜绿假单胞菌模型中，群体感应是正常生物膜成熟和毒力所必需的。有多个群体感应回路控制着几十个代表潜在毒力位点的特定基因的表达。
Recent advances in studies of bacterial gene expression have brought the realization that cell-to-cell communication and community behavior are critical for successful interactions with higher organisms. Species-specific cell-to-cell communication is involved in successful pathogenic or symbiotic interactions of a variety of bacteria with plant and animal hosts. One type of cell-cell signaling is acyl-homoserine lactone quorum sensing in Gram-negative bacteria. This type of quorum sensing represents a dedicated communication system that enables a given species to sense when it has reached a critical population density in a host, and to respond by activating expression of genes necessary for continued success in the host. Acyl-homoserine lactone signaling in the opportunistic: animal and plant pathogen Pseudomonas aeroginosa is a model for the relationships among quorum sensing, pathogenesis, and community behavior, In the P. aeroginosa model, quorum sensing is required for normal biofilm maturation and for virulence. There are multiple quorum-sensing circuits that control the expression of dozens of specific genes that represent potential virulence loci.