Gene Exchange and the Origin of Giant Viruses
Gene Exchange and the Origin of Giant Viruses
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DOI：
10.1159/000312920
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发表时间：
2010-01-01
期刊：
影响因子：
4.6
通讯作者：
Chandler, Michael
中科院分区：
文献类型：
--
作者：
Filee, Jonathan;Chandler, Michael
巨病毒或核质大DNA病毒（NCLDV）感染广泛的真核宿主（包括藻类、变形虫和后生动物），并且显示出非常大的基因组大小范围（在100 kb和1.2 Mb之间）。在这里，我们回顾了最近的一些结果，广泛的横向基因转移似乎已经发生在NCLDV的进化。目前的数据表明，巨型病毒可能起源于一个简单而古老的病毒祖先，该病毒祖先具有30-35个编码复制和结构蛋白的基因的小子集。来自不同细胞来源的大量横向基因转移，包括几个移动的遗传元件家族，可能是现存巨型病毒基因组大小和组成巨大多样性的原因。版权所有（C）2010 S. Karger AG，巴塞尔
Giant viruses or nucleocytoplasmic large DNA viruses (NCLDVs) infect a wide range of eukaryotic hosts (including, algae, amoebae and metazoans) and show a very large range in genome size (between 100 kb and 1.2 Mb). Here we review some recent results concerning the extensive lateral gene transfer which appears to have occurred during NCLDV evolution. Current data suggest that giant viruses probably originated from a simple and ancient viral ancestor with a small subset of 30-35 genes encoding replication and structural proteins. A large array of lateral gene transfers from diverse cellular sources, including several families of mobile genetic elements, is probably responsible for the huge diversity of genome size and composition found in extant giant viruses. Copyright (C) 2010 S. Karger AG, Basel