Rules and regulation in the primary structure of chromatin
Rules and regulation in the primary structure of chromatin
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DOI：
10.1016/j.ceb.2007.04.006
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发表时间：
2007-06-01
影响因子：
7.5
通讯作者：
Ahmad, Kami
中科院分区：
文献类型：
--
作者：
Rando, Oliver J.;Ahmad, Kami
将DNA包裹在核小体中影响因子与同源位点的结合，因此核小体在真核生物基因组中的位置有助于基因调控。核小体的定位受DNA序列、染色质重塑因子和非组蛋白染色质因子的影响，目前正在构建核小体的基因组图谱。然而，对这些图谱的解释需要考虑染色质动力学，因为即使是一些定位的核小体也会迅速解绕和排出。核小体的动态特性参与了几个过程，包括基因调控、转录机制和染色质状态的遗传。了解核小体的位置和动态行为有望揭示为什么转录因子结合的位点比预测的要少得多，组蛋白变异如何被靶向，以及染色质状态如何被描绘。
Wrapping DNA into a nucleosome influences factor binding to cognate sites, and thus the positions of nucleosomes in eukaryotic genomes contribute to gene regulation. Nucleosome positioning is influenced by DNA sequence, chromatin remodelers and non-histone chromatin factors, and genomic maps of nucleosomes are now being constructed. However, interpretation of these maps requires consideration of chromatin dynamics, as even some positioned nucleosomes appear subject to rapid unwinding and eviction. The dynamic properties of nucleosomes contribute to several processes, including gene regulation, mechanisms of transcription and the inheritance of chromatin states. Understanding the positions and dynamic behavior of nucleosomes promises to shed light on why transcription factors bind so many fewer sites than predicted, how histone variants may be targeted, and how chromatin states are delineated.