Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population
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DOI：
10.1093/carcin/bgx113
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发表时间：
2018-03-01
期刊：
影响因子：
4.7
通讯作者：
Amos, Christopher I.
中科院分区：
文献类型：
--
作者：
Li, Yafang;Xiao, Xiangjun;Amos, Christopher I.
非小细胞肺癌是最常见的肺癌类型。环境和遗传危险因素都有助于肺癌的发生。我们在欧洲血统人群中进行了单核苷酸多态性（SNP）与吸烟状态（从不吸烟者与曾经吸烟者）之间的全基因组相互作用分析。在发现阶段，我们采用了两步分析策略：首先，我们使用13 336例非小细胞肺癌病例进行了仅病例交互作用分析，以评估SNP与吸烟行为之间的关系。具有P值的候选SNP
Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never-versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13 336 non-small cell lung cancer cases. Candidate SNPs with P-value