NARCOTIC PROPERTIES OF CARBON DIOXIDE IN DOG
NARCOTIC PROPERTIES OF CARBON DIOXIDE IN DOG
复制标题
DOI：
10.1097/00000542-196709000-00019
复制
发表时间：
1967-01-01
期刊：
影响因子：
8.8
通讯作者：
MUALLEM, M
中科院分区：
文献类型：
--
作者：
EISELE, JH;EGER, EI;MUALLEM, M
在动脉pH值为7.64至7.10的情况下，15毫米至95毫米汞的PacO2对氟烷在狗体内的最低麻醉浓度（MAC）没有影响。水银浓度高于95毫米，而动脉pH值低于7.10，逐渐使人麻醉，取代了维持麻醉深度不变所需的氟烷。在PaCO2为245毫米汞柱的情况下，仅用CO2麻醉。CO2 -cosis的机制与脑池CSF[脑脊液]测量的脑内pH变化相关良好（P>0.05），似乎与动脉pH、PaCO2和脑脊液PCO2无关。
PacO2 ranging from 15 mm. to 95 mm. of mercury with arterial pH values from 7.64 to 7.10 had no effect on the minimum anesthetic concentration (MAC) for halothane in dogs. levels above 95 mm. of mercury with arterial pH below 7.10 were progressively narcotic, and replaced the halothane required to maintain a constant depth of anesthesia. Anesthesia was achieved with CO2 alone at PaCO2 of 245 mm. of mercury. The mechanism of CO2 nar-cosis correlated well (P>0.05) with the pH changes in the brain as measured in the cisternal CSF [cerebral spinal fluid], and appeared to be independent of arterial pH, PaCO2, and CSF PCO2.