Factors Associated with Meniscal Extrusion in Knees with or at Risk for Osteoarthritis: The Multicenter Osteoarthritis Study
Factors Associated with Meniscal Extrusion in Knees with or at Risk for Osteoarthritis: The Multicenter Osteoarthritis Study
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DOI：
10.1148/radiol.12110986
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发表时间：
2012-08-01
期刊：
影响因子：
19.7
通讯作者：
Guermazi, Ali
中科院分区：
文献类型：
--
作者：
Crema, Michel D.;Roemer, Frank W.;Guermazi, Ali
目的：评估半月板撕裂、膝关节排列不齐、软骨损伤、膝关节积液和体重指数与半月板脱出的关系。材料和方法：多中心骨关节炎研究是一项对有或有膝关节骨关节炎(OA)风险的个体进行的观察性研究。符合HIPAA的方案得到了所有参与中心的机构审查委员会的批准，并获得了所有患者的书面知情同意。所有的受试者都有可用的基线膝关节X线片和磁共振(MR)图像。由两名肌肉骨骼放射科医生使用全器官磁共振成像评分系统对半月板形态特征、半月板位置和软骨形态特征进行磁共振成像评估。结果：共1527名受试者(2131膝，2116膝，2106膝)与半月板撕裂严重程度、膝关节对齐不良、胫股软骨损伤、膝关节积液、体重指数与半月板脱出的横断面关系进行了Logistic回归分析。在内侧，半月板撕裂、内翻排列不良和软骨损伤与半月板挤压有关，优势比(OR)分别为6.3(95%可信区间：5.0，8.0)、1.3(95%可信区间：1.1，1.7)和1.8(95%可信区间：1.4，2.2)。半月板撕裂、外翻对位和软骨损伤与半月板脱出有关，OR值分别为10.3(95%CI：7.1，14.9)、2.2(95%CI：1.5，3.2)和2.0(95%CI：1.3，2.9)。结论：半月板撕裂不是半月板脱出的唯一相关因素，其他因素还包括膝关节排列不良和软骨损伤。半月板挤压可能是骨关节炎过程中关节组织间复杂的相互作用和机械应力作用的结果。(C)RSNA，2012年
Purpose: To assess the associations of meniscal tears, knee malalignment, cartilage damage, knee effusion, and body mass index with meniscal extrusion.Materials and Methods: The Multicenter Osteoarthritis study is an observational study of individuals who have or are at risk for knee osteoarthritis (OA). The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informed consent was obtained from all patients. All subjects with available baseline knee radiographs and magnetic resonance (MR) images were included. MR imaging assessment of meniscal morphologic characteristics, meniscal position, and cartilage morphologic characteristics with use of the Whole-Organ Magnetic Resonance Imaging Score system was performed by two musculoskeletal radiologists. Cross-sectional associations of severity of meniscal tears, knee malalignment, tibiofemoral cartilage damage, knee effusion, and body mass index with meniscal extrusion were assessed by using logistic regression, with multiadjustments when testing each predictor.Results: A total of 1527 subjects (2131 knees; 2116 medial and 2106 lateral menisci) were included. Medially, meniscal tears, varus malalignment, and cartilage damage were associated with meniscal extrusion, with odds ratios (ORs) of 6.3 (95% confidence interval [CI]: 5.0, 8.0), 1.3 (95% CI: 1.1, 1.7), and 1.8 (95% CI: 1.4, 2.2), respectively. Laterally, meniscal tears, valgus malalignment, and cartilage damage were associated with meniscal extrusion, with ORs of 10.3 (95% CI: 7.1, 14.9), 2.2 (95% CI: 1.5, 3.2), and 2.0 (95% CI: 1.3, 2.9), respectively.Conclusion: Meniscal tears are not the only factors associated with meniscal extrusion; other factors include knee malalignment and cartilage damage. Meniscal extrusion is probably an effect of the complex interactions among joint tissues and mechanical stresses involved in the OA process. (c) RSNA, 2012