Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
复制标题
果蝇 NF-kappaB/IkappaB 蛋白 relish 的适应性进化。
DOI：
10.1093/genetics/154.3.1231
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发表时间：
2000
期刊：
影响因子：
3.3
通讯作者：
Whitley,P
中科院分区：
文献类型：
--
作者：
Begun,DJ;Whitley,P
NF-κB and IκB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-κB/IκB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IκB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.
