[Research Updates: Cariogenic Mechanism of Streptococcus mutans].
[Research Updates: Cariogenic Mechanism of Streptococcus mutans].
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DOI：
10.12182/20220360508
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发表时间：
2022-03-01
期刊：
影响因子：
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通讯作者：
Lin, Huan-Cai
中科院分区：
文献类型：
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作者：
Chen, Dong-Ru;Lin, Huan-Cai
龋齿患病率仍然很高，给全球社会的公共卫生带来了重大负担。微生物是引起龋齿的主要原因，其中变形链球菌（S. mutans）是最被广泛认可的致龋菌之一。近年来，研究技术的进步使得学术界对变形链球菌的致龋性在DNA、RNA和蛋白质水平上进行了更加深入的研究，从而对变形链球菌的表面结构和细胞外基质组成有了新的认识。本文对变形链球菌致龋机制的最新研究成果进行综述，以期为未来开发针对变形链球菌的防龋药物揭示更多的靶点和潜在途径，推动防龋运动的发展。
The prevalence of dental caries remains high, posing a major burden on the public health of the global society. Microorganisms are the main cause of dental caries, among which Streptococcus mutans ( S. mutans) is one of the most widely recognized cariogenic bacteria. In recent years, the progress in research technology enabled the academic circle to conduct more in-depth research into caries-inducing S. mutans at the DNA, RNA and protein levels, and to gain thereby a new understanding of the surface structure and extracellular matrix composition of S. mutans. In this paper, we summarized recent findings on the cariogenic mechanism of S. mutans in order to help reveal more targets and potential approaches for the future development of caries prevention agents that target S. mutans, and to promote the development of dental caries prevention campaign.