DIFFERENTIATION OF SENSORIMOTOR NEURONAL STRUCTURES RESPONSIBLE FOR INDUCTION OF MOTOR EVOKED-POTENTIALS, ATTENUATION IN DETECTION OF SOMATOSENSORY STIMULI, AND INDUCTION OF SENSATION OF MOVEMENT BY MAPPING OF OPTIMAL CURRENT DIRECTIONS
DIFFERENTIATION OF SENSORIMOTOR NEURONAL STRUCTURES RESPONSIBLE FOR INDUCTION OF MOTOR EVOKED-POTENTIALS, ATTENUATION IN DETECTION OF SOMATOSENSORY STIMULI, AND INDUCTION OF SENSATION OF MOVEMENT BY MAPPING OF OPTIMAL CURRENT DIRECTIONS
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DOI：
10.1016/0168-5597(94)90045-0
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发表时间：
1994-06-01
期刊：
影响因子：
--
通讯作者：
HALLETT, M
中科院分区：
文献类型：
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作者：
PASCUALLEONE, A;COHEN, LG;HALLETT, M
经颅磁刺激（TMS）可以引起运动诱发电位（MEPs），体感刺激（ADSS）检测衰减和运动感觉（SOM）涉及同一身体部位。在这项研究中，我们试图区分负责这些影响的底物。6名正常志愿者；经颅磁刺激采用近单极Dantec刺激器和蝶形线圈。确定在短拇外展肌（APB）、第一背骨间肌（FDI）和指小内收肌（ADM）诱导mep的最佳头皮位置和电流方向；缺血性麻痹手2、5指SOM；ADSS应用于数字2和5。所有3块肌肉的mep和双指的SOM和ADSS在单一头皮位置被最佳激活。在所有科目中，MEPs的最佳电流方向都指向前方；ADSS和SOM的指向后。最佳电流方向显示所有受试者的MEPs （ADM、FDI和APB从前外侧到前内侧）、ADSS（5号手指后内侧、2号手指后外侧）和SOM（1至5号手指后外侧到后内侧）的进展相同。我们得出结论，针对负责mep的皮质脊髓神经元的神经网络与导致SOM和ADSS的神经网络不同（无法区分）。
Transcranial magnetic stimulation (TMS) of the sensorimotor cortex can evoke motor evoked potentials (MEPs), attenuation in detection of somatosensory stimuli (ADSS), and sensation of movement (SOM) referred to the same body part. In this study we tried to differentiate the substrates responsible for these effects. In 6 normal volunteers; TMS was applied with a nearly monopolar Dantec stimulator and a butterfly coil. Optimal scalp location and current direction were determined for induction of MEPs in abductor pollicis brevis (APB), first dorsal interosseous (FDI), and adductor digiti minimi (ADM); SOM in digits 2 and 5 in an ischemically paralyzed hand; and ADSS applied to digits 2 and 5. All 3 muscles' MEPs and SOM and ADSS in both digits were optimally activated from a single scalp position. In all subjects, optimal current directions for MEPs pointed anteriorly; those for ADSS and SOM pointed posteriorly. Optimal current directions showed the same progression in all subjects for MEPs (ADM, FDI, and APB from antero-lateral to antero-medial), ADSS (digit 5 postero-medial, 2 postero-lateral), and SOM (digit 1 through 5 postero-lateral to postero-medial). We conclude that neuronal networks targeting corticospinal neurons responsible for MEPs are different from those leading to SOM and ADSS (which could not be differentiated).