Viscosities of implantable biomaterials in vocal fold augmentation surgery
Viscosities of implantable biomaterials in vocal fold augmentation surgery
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DOI：
10.1097/00005537-199805000-00019
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发表时间：
1998-05-01
期刊：
影响因子：
2.6
通讯作者：
Titze, IR
中科院分区：
文献类型：
--
作者：
Chan, RW;Titze, IR
声带振动在很大程度上取决于声带组织的粘弹性。例如，发声阈压（一种衡量发声“难易程度”的指标）已被证明与振动粘膜的黏度直接相关。各种植入式生物材料已被用于声带隆胸手术，植入点有时接近或在粘膜内。然而，它们的粘度或其他机械性能却很少为人所知。本研究试图提供常用声外科生物材料的黏度数据。使用平行板旋转流变仪，对可植入的聚四氟乙烯（Teflon或Polytef； Mentor Inc., Hingham， MA）、胶原蛋白（Zyderm; collagen Corp., Pale Alto， CA）、戊二醛交联（GAX）胶原蛋白（Phonagel或Zyplast； collagen Corp.）、可吸收明胶（Gelfoam; Upjohn Co., Kalamazoo， MI）和人腹部皮下脂肪进行振荡剪切实验。在10 Hz和37℃的正弦振荡剪切下，聚四氟乙烯的动态粘度为116 Pa-s，明胶为21 Pa-s，两种胶原蛋白为8-13 Pa-s，脂肪为3 Pa-s，声带粘膜为1 ~ 3 Pa-s。外推到100 Hz的结果也显示出生物材料之间的类似差异，但由于聚合物和生物材料的典型逆频率关系（剪切变薄效应），所有值都要低一个数量级。数据表明，使用脂肪进行声带增强可能更有利于“轻松”发声，因为它的粘度相对较低，最接近生理水平。在植入的生物材料没有任何显著的同化（例如，再吸收和纤维化）之前，这一含义可能是预测术后语音的初始结果最相关的。
Vocal fold vibration depends critically on the viscoelasticity of vocal fold tissues. For instance, phonation threshold pressure, a measure of the "ease" of phonation, has been shown to be directly related to the viscosity of the vibrating mucosa. Various implantable biomaterials have been used in vocal fold augmentation surgery, with implantation sites sometimes close to or inside the mucosa. Yet their viscosities or other mechanical properties are seldom known. This study attempts to provide data on viscosities of commonly used phonosurgical biomaterials. Using a parallel-plate rotational rheometer, oscillatory shear experiments were performed on implantable polytetrafluoroethylene (Teflon or Polytef; Mentor Inc., Hingham, MA), collagen (Zyderm; Collagen Corp., Pale Alto, CA), glutaraldehyde crosslinked (GAX) collagen (Phonagel or Zyplast; Collagen Corp.), absorbable gelatin (Gelfoam; Upjohn Co., Kalamazoo, MI), and human abdominal subcutaneous fat. Samples of human vocal fold mucosal tissues were also tested, Under sinusoidal oscillatory shear at 10 Hz and at 37 degrees C, the dynamic viscosity was 116 Pascal-seconds (Pa-s) for polytetrafluoroethylene, 21 Pa-s for gelatin, 8-13 Pa-s for the two types of collagen, 3 Pa-s for fat, and 1 to 3 Pa-s for vocal fold mucosa. Results extrapolated to 100 Hz also show similar differences among the biomaterials, but all values are an order of magnitude lower because of the typical inverse frequency relation (shear thinning effect) for polymeric and biologic materials. The data suggest that the use of fat for vocal fold augmentation may be more conducive to the "ease" of phonation because of its relatively low viscosity, which is closest to physiologic levels. This implication is probably the most relevant in predicting initial outcome of the postoperative voice before there is any significant assimilation (e.g., resorption and fibrosis) of the implanted biomaterial.