Differential effects of chronic ethanol consumptions or thiamine deficiency on spatial working memory in Balb/c mice: A behavioral and neuroanatomical study
Differential effects of chronic ethanol consumptions or thiamine deficiency on spatial working memory in Balb/c mice: A behavioral and neuroanatomical study
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长期乙醇消耗或硫胺素缺乏对 Balb/c 小鼠空间工作记忆的不同影响：行为和神经解剖学研究
DOI：
10.1016/0304-3940(91)90152-j
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发表时间：
1991
影响因子：
2.5
通讯作者：
R. Jaffard
中科院分区：
文献类型：
--
作者：
A. Tako;D. Béracochéa;L. Lescaudron;R. Jaffard
这项研究的目的是比较硫胺素缺乏和慢性酒精摄入对记忆和乳头体正中核内神经元密度的影响。结果表明，酒精处理(48周)的小鼠在顺序交替任务中表现出行为障碍，其特征是交替频率随着试验次数的增加而逐渐下降；在对照组和硫胺素缺乏的受试者中没有观察到这种缺陷。组织切片的定量分析表明，酒精治疗后，乳头体内的神经元密度显著降低，但硫胺素缺乏后并不明显。
This study was aimed to compare the effects of either a thiamine deficiency or a chronic ethanol consumption on memory and on neuronal density within the median mammillary nucleus. Results showed that alcohol-treated (48 weeks) mice exhibited a behavioral impairment in a sequential alternation task characterized by a progressive decay of alternation rates as a function of the number of trials; such a deficit was not observed in controls and thiamine-deficient subjects. A quantitative analysis using histological sections showed an important reduction of neuronal density within the mammillary bodies following the alcohol treatment but not following thiamine deficiency.