Repetitive Drug Delivery Using Light-Activated Liposomes for Potential Antimicrobial Therapies.
Repetitive Drug Delivery Using Light-Activated Liposomes for Potential Antimicrobial Therapies.
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DOI：
10.1016/j.addr.2022.114395
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发表时间：
2022-06
影响因子：
16.1
通讯作者：
Zheng Yuan;Catherine Gottsacker;Xingyu He;Thomas Waterkotte;Yoonjee C. Park
中科院分区：
文献类型：
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作者：
Zheng Yuan;Catherine Gottsacker;Xingyu He;Thomas Waterkotte;Yoonjee C. Park
过度使用或滥用抗生素及其在环境中的残留物导致耐药细菌的出现和流行，并导致严重的健康问题。脂质体在药物传递方面的研究取得了显著进展，一些脂质体药物由于其生物相容性和改善的功效而被批准用于临床。最近，脂质体已经被进一步工程化以响应于外部刺激（例如光、pH和热）以剂量控制的方式在感兴趣的靶标上释放封装的药物。其中，光激活脂质体药物递送获得了很多关注，因为药物在靶向部位的释放可以通过改变激光/光的持续时间、能量和光束面积来精确控制。我们展望了光激活脂质体递送系统在有效耐药抗菌治疗中的潜在应用。如果药物的量在靶位置被精确地控制延长的时间，则光激活脂质体的使用将在抗微生物疗法中广泛传播。本文就各种光激活脂质体给药技术的研究进展进行综述。重点介绍了光激活脂质体的重复释放机制和应用，因为重复性提供了药物递送系统的稳定性和精确控制，以防止抗生素过量和以最小剂量治疗。我们描述了从临床前到临床环境的翻译限制以及克服这些限制的策略。在选择和设计成功应用的药物递送系统时，仔细考虑光响应材料、脂质成分、激光参数和激光安全性是重要的。
Overuse or misuse of antibiotics and their residues in the environment results in the emergence and prevalence of drug-resistant bacteria and leads to serious health problems. Notable progress in liposome research has been made in drug delivery and several liposomal drugs have been approved for clinical use owing to its biocompatibility and improved efficacy. Recently, liposomes have been engineered further to release encapsulated drugs on the target of interest in a dose-controlled fashion in response to external stimuli such as light, pH, and heat. Among those, light-activated liposomal drug delivery gained a lot of attention because drug release at the targeted sites can be precisely controlled by varying laser/light duration, energy and beam area. We envision potential applications of the light-activated liposomal delivery systems for effective drug-resistant antimicrobial therapies. The use of light-activated liposomes will be widely spread in antimicrobial therapies if the amount of drug is precisely controlled for a prolonged time at a target location. In this review, we discussed the breadth and depth of various light-activated liposomal drug delivery technology. Emphasis was given to repetitive release mechanism and applications of light-activated liposomes because the repeatability provides stability and precise control of the drug delivery system to prevent overdose of antimicrobials and treat with minimal doses. We described limitations on translation from pre-clinical to clinical settings and strategies to overcome the limitations. Careful consideration of light-responsive materials, lipid composition, laser parameters and laser safety is important when selecting and designing the drug delivery system for successful applications.