Informing shigellosis prevention and control through pathogen genomics
Informing shigellosis prevention and control through pathogen genomics
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DOI：
10.1101/2021.06.09.447709
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
Rebecca J. Bengtsson;A. Simpkin;Caisey V. Pulford;Ross Low;D. Rasko;D. Rigden;N. Hall;E. Barry;S. Tennant;K. Baker
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文献类型：
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作者：
Rebecca J. Bengtsson;A. Simpkin;Caisey V. Pulford;Ross Low;D. Rasko;D. Rigden;N. Hall;E. Barry;S. Tennant;K. Baker
志贺氏杆菌是低收入和中等收入国家（LMIC）严重儿童腹泻的主要细菌病因，对抗菌素的耐药性日益增强，而且没有获得许可的疫苗。我们对从七个LMIC系统收集的1246株志贺氏菌进行了基因组分析，以告知控制和确定可能限制当前方法有效性的因素。研究发现，相对于其基因组多样性，索内沙门氏菌的致病率是其他志贺氏菌的20倍以上，并强调了福氏沙门氏菌之间存在的多样性和适应能力，这些多样性和适应能力可能在<6个月的时间内产生疫苗逃逸变异。此外，我们显示对当前推荐的抗菌素志贺菌的耐药性趋同进化。这表明迫切需要将现有的基因组多样性纳入志贺氏菌和其他病原体的疫苗和治疗计划中。
Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low- and middle-income countries (LMIC), are increasingly antimicrobial resistant and have no licensed vaccine. We performed genomic analyses of 1246 systematically collected shigellae from seven LMIC to inform control and identify factors that could limit the effectiveness of current approaches. We found that S. sonnei contributes ≥20-fold more disease than other Shigella species relative to its genomic diversity and highlight existing diversity and adaptative capacity among S. flexneri that may generate vaccine escape variants in <6 months. Furthermore, we show convergent evolution of resistance against the current recommended antimicrobial among shigellae. This demonstrates the urgent need to integrate existing genomic diversity into vaccine and treatment plans for Shigella, and other pathogens.