The global burden of disease for skin, lung, and bladder cancer caused by arsenic in food.
The global burden of disease for skin, lung, and bladder cancer caused by arsenic in food.
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DOI：
10.1158/1055-9965.epi-13-1317
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Wu F
中科院分区：
文献类型：
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作者：
Oberoi S;Barchowsky A;Wu F
砷是一种普遍存在的天然类金属，对人类癌症构成重大风险。虽然人类接触的大部分是水，但世界各地数百万人通过谷物、蔬菜、肉类和鱼类中自然产生的砷水平以及通过用含砷水加工的食品大量暴露于砷。因此，我们估计了可归因于食物中无机砷的全球膀胱癌、肺癌和皮肤癌的疾病负担。为了确定全球范围内食源性无机砷的暴露，我们使用了世界卫生组织对13个国家组的食品消费量的估计，并结合对不同食品中总砷和无机砷的报告测量。我们估计了与砷相关的膀胱癌和肺癌的斜率系数，并使用美国环境保护局皮肤癌斜率系数来计算每个国家/地区群内男性和女性癌症发病率的年度风险。我们估计，全球每年新增9,129至119,176例膀胱癌病例，11,844至121,442例肺癌病例，10,729至110,015例皮肤癌病例可归因于食物中的无机砷。这些估计表明，食源性砷暴露造成了严重的全球人类疾病负担。估计食物中砷暴露造成的全球癌症负担将支持减少疾病暴露、促进环境危害的政策。
Arsenic is a ubiquitous, naturally occurring metalloid that poses a significant human cancer risk. While water consumption provides the majority of human exposure, millions of individuals worldwide are significantly exposed to arsenic through naturally occurring levels of arsenic in grains, vegetables, meats and fish, as well as through food processed with water containing arsenic. Thus, we estimated the global burdens of disease for bladder, lung and skin cancers attributable to inorganic arsenic in food. To determine foodborne inorganic arsenic exposures worldwide, we used World Health Organization estimates of food consumption in thirteen country clusters, in conjunction with reported measurements of total and inorganic arsenic in different foods. We estimated slope factors for arsenic related bladder and lung cancers, and used the US Environmental Protection Agency skin cancer slope factor, to calculate the annual risk of the cancer incidence in males and females within each country cluster. We estimated that each year 9,129 to 119,176 additional cases of bladder cancer, 11,844 to 121,442 of lung cancer, and 10,729 to 110,015 of skin cancer worldwide are attributable to inorganic arsenic in food. These estimates indicate that foodborne arsenic exposure causes a significant global burden of human disease. Estimating the global cancer burden caused by arsenic exposure in food will support policies that reduce exposure to disease promoting environmental hazards.