Mitotically-associated long non-coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by downregulating miR-122a.
Mitotically-associated long non-coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by downregulating miR-122a.
复制标题
有丝分裂相关的长非编码 RNA 通过下调 miR-122a 促进肝细胞癌中的癌细胞增殖。
作者：
Xuejing Zhang;Hongling Li;Ming;Xiangyang Wang;Jingjing Zheng;Shun
有丝分裂相关长非编码RNA (MANCR) 与恶性乳腺癌有关。本研究分析了 MANCR 在肝细胞癌 (HCC) 中的作用。研究发现 MANCR 在 HCC 中表达上调，并且癌组织中 MANCR 的高表达水平预示着 HCC 患者的生存率较差。 MicroRNA (miR)-122a 在 HCC 中下调，并且仅在癌症组织中与 MANCR 呈负相关。 MANCR过表达导致miR-122a下调，而miR-122a过表达对MANCR表达无明显影响。 MANCR过表达对HCC细胞增殖没有显着影响，但会促进细胞迁移和侵袭。 miR-122a 过表达导致 HCC 细胞的迁移和侵袭受到抑制，并减弱 MANCR 过表达的影响。因此，lncRNA MANCR可能通过下调miR-122a促进HCC癌细胞增殖。
Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)-122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR-122a, while miR-122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. Therefore, lncRNA MANCR may promote cancer cell proliferation in HCC by downregulating miR-122a.
影响因子：
29.4
作者：
Kanwal F;Hoang T;Kramer JR;Asch SM;Goetz MB;Zeringue A;Richardson P;El-Serag HB
通讯作者：
El-Serag HB
影响因子：
8
作者：
Spizzo R;Almeida MI;Colombatti A;Calin GA
通讯作者：
Calin GA