PET/MR images acquired with a compact MR-compatiable PET detector in a 7-T magnet
PET/MR images acquired with a compact MR-compatiable PET detector in a 7-T magnet
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DOI：
10.1148/radiol.2443061756
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发表时间：
2007-09-01
期刊：
影响因子：
19.7
通讯作者：
Pichler, Bernd J.
中科院分区：
文献类型：
--
作者：
Judenhofer, Martin S.;Catana, Ciprian;Pichler, Bernd J.
目的：为了前瞻性地使用紧凑型雪崩光电二极管，而不是光电倍增管集成的正电子发射断层扫描（PET）探测器和7-T磁共振（MR）imager.Materials和方法：所有的动物实验按照蒂宾根大学的指南和德国的动物保护法。一个紧凑的氧正硅酸镥雪崩光电二极管PET探测器的建立和优化内运行的7-T MR成像仪。在磁体外部和内部研究了探测器性能，并在使用和不使用PET探测器的情况下评价了MR图像质量。两个PET探测器被设置成彼此相对，并在巧合中操作，以获取PET图像的步骤和拍摄模式，在小鼠头部标本注射氟18氟脱氧葡萄糖后，结果：PET探测器的性能时，在磁共振图像采集过程中的磁铁内的能量分辨率（从14.6%增加到15.9%）显示出很小的退化。PET探测器不影响MR成像。融合的PET和MR图像显示解剖匹配，图像质量没有下降。结论：同时PET和MR成像与7-T系统被认为是可行的。
Purpose: To prospectively use compact avalanche photodiodes instead of photomultiplier tubes to integrate a positron emission tomographic (PET) detector and a 7-T magnetic resonance (MR) imager.Materials and Methods: All animal experiments were performed in accordance with the University of Tubingen guidelines and the German law for the protection of animals. A compact lutetium oxyorthosilicate-avalanche photodiode PET detector was built and optimized to operate within a 7-T MR imager. The detector performance was investigated both outside and inside the magnet, and MR, image quality was evaluated with and without the PET detector. Two PET detectors were set up opposite each other and operated in coincidence to acquire PET images in the step-and-shoot mode in a mouse head specimen after injection of fluorine 18 fluorodeoxyglucose.Results: The performance of the PET detector when operated inside the magnet during MR image acquisition showed little degradation in energy resolution (increase from 14.6% to 15.9%). The PET detector did not influence MR imaging. The fused PET and MR images showed an anatomic match and no degradation of image quality.Conclusion: Simultaneous PET and MR imaging with a 7-T system was deemed feasible.