Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
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DOI：
10.1016/j.mad.2006.11.016
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发表时间：
2007-01-01
影响因子：
5.3
通讯作者：
Salvioli, Stefano
中科院分区：
文献类型：
--
作者：
Franceschi, Claudio;Capri, Miriam;Salvioli, Stefano
包括免疫衰老在内的大部分衰老表型是由炎症和抗炎网络之间的不平衡解释的，这导致了我们提出称为炎症的低度慢性促炎状态。从这个角度来看，健康的老龄化和长寿可能不仅是较低的倾向，安装炎症反应的结果，而且有效的抗炎网络，这在正常的老化不能完全中和炎症过程，随之而来的终身抗原负担和暴露于破坏剂。这种全球失衡可能是脆弱和常见年龄相关疾病的主要驱动力，应该在基于进化的系统生物学视角下加以解决和研究。支持这种概念化的证据主要来自人类研究。因此，我们提出，炎症可以两侧抗炎作为主要的决定因素，不仅免疫衰老，但最终的全球老化和长寿。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies, and should be addressed and studied within an evolutionary-based systems biology perspective. Evidence in favor of this conceptualization largely derives from studies in humans. We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.