Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms.
Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms.
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DOI：
10.1007/s11684-011-0114-1
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发表时间：
2011-03-01
影响因子：
8.1
通讯作者：
Jiang, Jianxin
中科院分区：
文献类型：
--
作者：
Li, Li;Jiang, Jianxin
成体干细胞在伤口愈合和组织再生方面有很大的前景。例如，间充质干细胞（MSC）已被证明在组织修复中发挥作用。研究表明，内源性骨髓间充质干细胞或外源性骨髓间充质干细胞迁移到损伤部位并参与修复过程。尽管报道了多种信号传导途径和分子，包括伤口处的化学吸引因子和内源性电场，但MSC迁移到损伤组织中的确切机制仍不完全清楚。本文就骨髓间充质干细胞迁移的调控因素和信号转导途径作一综述。更好地了解参与MSC迁移的分子机制将有助于我们在再生医学中开发新的基于干细胞的治疗策略。
Adult stem cells hold great promise for wound healing and tissue regeneration. Mesenchymal stem cells (MSCs), for example, have been shown to play a role in tissue repair. Research has shown that endogenous bone marrow MSCs or exogenously delivered MSCs migrate to the sites of injury and participate in the repair process. The precise mechanisms underlying migration of MSCs into the injured tissue are still not fully understood, although multiple signaling pathways and molecules were reported, including both chemoattractive factors and endogenous electric fields at wounds. This review will briefly summarize the regulatory facors and signaling transduction pathways involved in migration of MSCs. A better understanding of the molecular mechanisms involved in the migration of MSCs will help us to develop new stem cell-based therapeutic strategies in regenerative medicine.