ParaHox gene expression in the polychaete annelid Capitella sp I
ParaHox gene expression in the polychaete annelid Capitella sp I
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DOI：
10.1007/s00427-005-0049-0
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发表时间：
2006-02-01
影响因子：
2.4
通讯作者：
Seaver, EC
中科院分区：
文献类型：
--
作者：
Fröbius, AC;Seaver, EC
Hox和ParaHox基因是两侧对称动物胚胎发育的重要转录调节因子，被认为起源于一个祖先的原Hox/ParaHox簇。Hox基因在原口动物和后口动物的基因组中均成簇，并且在簇中基因的位置与其沿动物体轴沿着表达的位置之间存在特定关系（共线性）。目前尚不清楚ParaHox基因Gsx、Xlox和Cdx是否通常表现出类似的现象，因为尚未描述任何原口动物在单一物种内所有三种ParaHox基因的发育表达。在这里，我们显示了所有三个ParaHox基因在多毛类Capitella属的空间和时间定位。我，一个成员的一个形态上最多样化和研究不足的群体内的后生动物，Lophotrochozoa。我们的数据表明，虽然CapI-Xlox和CapI-Cdx都在肠道中区域表达，但三个Capitella sp. I ParaHox基因作为一个组并不完全符合时间或空间共线性的预测。相反，存在与特定组织的发育相关的跨物种表达的保守性，并且ParaHox基因表达起始的相对顺序可能反映个体发育期间物种特异性组织发育的相对顺序。
Hox and ParaHox genes are transcriptional regulators vital for many aspects of embryonic development in bilaterian animals and are considered to have originated from one ancestral proto-Hox/ParaHox cluster. Hox genes are clustered in the genome of both protostomes and deuterostomes, and there is a specific relationship between the position of a gene in the cluster and the position of its expression along the animal body axis (colinearity). It is not clear whether the ParaHox genes Gsx, Xlox, and, Cdx generally exhibit a similar phenomenon since developmental expression for all three ParaHox genes within a single species has not yet been described for any protostome animal. Here we show the spatial and temporal localization for all three ParaHox genes in the polychaete Capitella sp. I, a member of one of the morphologically most diverse and understudied groups within the Metazoa, the Lophotrochozoa. Our data demonstrate that although both CapI-Xlox and CapI-Cdx are regionally expressed in the gut, the three Capitella sp. I ParaHox genes as a group do not perfectly fit predictions of temporal or spatial colinearity. Instead, there is a conservation of expression across species associated with development of particular tissues, and the relative order of initiation of ParaHox gene expression likely reflects the relative order of species-specific tissue development during ontogenesis.