Soluble receptor of advanced glycation end products levels are related to ischaemic aetiology and extent of coronary disease in chronic heart failure patients, independent of advanced glycation end products levels New Roles for Soluble RAGE
Soluble receptor of advanced glycation end products levels are related to ischaemic aetiology and extent of coronary disease in chronic heart failure patients, independent of advanced glycation end products levels New Roles for Soluble RAGE
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DOI：
10.1093/eurjhf/hfq117
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发表时间：
2010-10-01
影响因子：
18.2
通讯作者：
Gonzalez-Juanatey, Jose R.
中科院分区：
文献类型：
--
作者：
Raposeiras-Roubin, Sergio;Rodino-Janeiro, Bruno K.;Gonzalez-Juanatey, Jose R.
晚期糖基化终产物（AGE）及其受体（AGE）和受体可溶性形式（AGE）在心力衰竭（HF）中的作用的知识非常有限。我们评估了AGE-CRP系统在HF中的临床作用，特别是它与缺血性病因的关系，我们检测了103例慢性HF患者的荧光AGE、糖化白蛋白和sCRP。我们发现，sodium而不是AGE与缺血病因有关（1638.3 +/- 207.4缺血组vs. 1065.1 +/- 94.2 pg/mL非缺血组; P =0.016），与年龄、性别、糖尿病、肾功能、临床严重程度或其他变量无关（OR：1.091; 95%CI（置信区间）：1.032-1.153; P =0.007）。此外，冠状动脉狭窄与冠状动脉病变程度直接相关（三支血管病变与非冠状动脉病变相比的OR：1.186; 95%CI：1.065-1.322; P =0.002）。我们还发现severity与HF严重程度之间存在相关性，随着纽约心脏协会（NYHA）分级的增加，severity增加（1类741.9 +/- 88.9 pg/mL，II类1195.9 +/- 113.2 pg/mL，和1724.8 +/- 245.7 pg/mL，III类（P < 0.05））和脑钠肽（BNP）水平（667.4 +/- 68.0 vs. 1344.5 +/- 126.0 pg/mL，BNP < and >= 400 pg/mL，sCRP是慢性心力衰竭严重程度的指标，并且是CHF患者中冠状动脉疾病及其严重程度的独立标志物。
Knowledge of the role of advanced glycation end products (AGE), their receptor (RAGE), and the receptor's soluble form (sRAGE), in heart failure (HF) is very limited. We evaluated the clinical role of the AGE-RAGE system in HF and in particular any association it might have with ischaemic aetiology.We measured fluorescent AGE, glycated albumin and sRAGE in 103 patients with chronic HF. We showed that sRAGE but not AGE was related to ischaemic aetiology (1638.3 +/- 207.4 ischaemic vs. 1065.1 +/- 94.2 pg/mL non-ischaemic group; P =0.016) independent of age, sex, diabetes, renal function, clinical severity, or other variables (OR: 1.091; 95% CI (confidence interval): 1.032-1.153; P =0.007). Moreover, sRAGE was directly associated with extent of coronary disease (OR for three vessel disease compared with non-coronary lesions: 1.186; 95% CI: 1.065-1.322; P =0.002). We also found a correlation between sRAGE and severity of HF, which increased with New York Heart Association (NYHA) class (741.9 +/- 88.9 pg/mL in class 1, 1195.9 +/- 113.2 pg/mL in class II, and 1724.8 +/- 245.7 pg/mL in class III (P < 0.05)) and brain natriuretic peptide (BNP) levels (667.4 +/- 68.0 vs. 1344.5 +/- 126.0 pg/mL for BNP < and >= 400 pg/mL, respectively).sRAGE is an indicator of chronic heart failure severity and an independent marker of coronary artery disease and its severity in patients with CHF.